CD86

Protein identityUniProt · HPA

UniProt accession

P42081

Gene

CD86

Ensembl

ENSG00000114013

Chromosome

3

Canonical length

329 aa

Protein class

CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Plasma membrane,Centriolar satellite

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>P42081|CD86
     1  MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL SELVVFWQDQ
    61  ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL QIKDKGLYQC IIHHKKPTGM
   121  IRIHQMNSEL SVLANFSQPE IVPISNITEN VYINLTCSSI HGYPEPKKMS VLLRTKNSTI
   181  EYDGVMQKSQ DNVTELYDVS ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ
   241  PPPDHIPWIT AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK
   301  IHIPERSDEA QRVFKSSKTS SCDKSDTCF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD86 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

33 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD86.

Disease | AutoantibodyPubMed

Conditions in which antibodies against CD86 are reported. Each links to that disease's full target list.

• Lupus Erythematosus, Systemic 3

ReferencesPubMed · IEDB

Publications for CD86 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.35

gnomAD pLI

0.95

gnomAD missense Z

1.08

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• B cell activation
• cell surface receptor signaling pathway
• cellular response to lipopolysaccharide
• immune response
• negative regulation of T cell activation
• negative regulation of T cell proliferation
• negative regulation of T cell receptor signaling pathway
• positive regulation of cell population proliferation
• positive regulation of DNA-templated transcription
• positive regulation of immunoglobulin production
• positive regulation of interleukin-2 production
• positive regulation of interleukin-4 production
• positive regulation of lymphotoxin A production
• positive regulation of non-canonical NF-kappaB signal transduction
• positive regulation of T cell proliferation
• positive regulation of T cell receptor signaling pathway
• positive regulation of T-helper 2 cell differentiation
• T cell activation
• T cell costimulation

Molecular functions

• coreceptor activity
• receptor ligand activity
• signaling receptor activity
• virus receptor activity

Cellular components

• cell surface
• centriolar satellite
• external side of plasma membrane
• extracellular exosome
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin V-set domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• T-cell Activation and Immune Regulation Protein
• Immunoglobulin V-set domain
• CD86, IgV domain

KeywordsUniProt

• Adaptive immunity
• Cell membrane
• Disulfide bond
• Glycoprotein
• Host cell receptor for virus entry
• Host-virus interaction
• Immunity
• Immunoglobulin domain
• Membrane
• Receptor
• Signal
• Transmembrane
• Transmembrane helix
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of CD86 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CD28
• MARCH8
• PHB1
• PHB2
• MARCHF8
• CTLA4