Seroatlas · Human Serome Atlas

STOML2

Stomatin-like protein 2, mitochondrial

Also known as: HSPC108, SLP-2, STML2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJZ1
Gene
STOML2
Ensembl
ENSG00000165283
Chromosome
9
Canonical length
356 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables GTPase binding activity; T cell receptor binding activity; and cardiolipin binding activity. Involved in intracellular calcium ion homeostasis; mitochondrion organization; and protein complex oligomerization. Acts upstream of or within T cell receptor signaling pathway. Located in several cellular components, including immunological synapse; membrane raft; and mitochondrial envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>Q9UJZ1|STOML2
     1  MLARAARGTG ALLLRGSLLA SGRAPRRASS GLPRNTVVLF VPQQEAWVVE RMGRFHRILE
    61  PGLNILIPVL DRIRYVQSLK EIVINVPEQS AVTLDNVTLQ IDGVLYLRIM DPYKASYGVE
   121  DPEYAVTQLA QTTMRSELGK LSLDKVFRER ESLNASIVDA INQAADCWGI RCLRYEIKDI
   181  HVPPRVKESM QMQVEAERRK RATVLESEGT RESAINVAEG KKQAQILASE AEKAEQINQA
   241  AGEASAVLAK AKAKAEAIRI LAAALTQHNG DAAASLTVAE QYVSAFSKLA KDSNTILLPS
   301  NPGDVTSMVA QAMGVYGALT KAPVPGTPDS LSSGSSRDVQ GTDASLDEEL DRVKMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STOML2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
153 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 153 nTPM
  • heart muscle: 109 nTPM
  • tongue: 104 nTPM
  • choroid plexus: 95 nTPM
  • liver: 87 nTPM
  • adrenal gland: 82 nTPM

Single-cell type

  • esophageal basal cells: 375 nCPM
  • oocytes: 332 nCPM
  • esophageal suprabasal cells: 308 nCPM
  • migrating cytotrophoblasts: 301 nCPM
  • gastric progenitor cells: 297 nCPM
  • extravillous trophoblasts: 277 nCPM

Immune cell

  • plasmacytoid DC: 122 nTPM
  • T-reg: 116 nTPM
  • total PBMC: 114 nTPM
  • NK-cell: 99 nTPM
  • myeloid DC: 98 nTPM
  • memory B-cell: 92 nTPM

Brain region

  • choroid plexus: 72 nTPM
  • thalamus: 44 nTPM
  • cerebellum: 42 nTPM
  • hypothalamus: 41 nTPM
  • cerebral cortex: 39 nTPM
  • midbrain: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
1.55
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STOML2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STOML2 as an antibody target. Whether an autoantibody or antibody against STOML2 could matter depends on whether native STOML2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STOML2 is annotated at the cell surface, where native STOML2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STOML2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STOML2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...