IGFBP6

Protein identityUniProt · HPA

UniProt accession

P24592

Gene

IGFBP6

Ensembl

ENSG00000167779

Chromosome

12

Canonical length

240 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>P24592|IGFBP6
     1  MTPHRLLPPL LLLLALLLAA SPGGALARCP GCGQGVQAGC PGGCVEEEDG GSPAEGCAEA
    61  EGCLRREGQE CGVYTPNCAP GLQCHPPKDD EAPLRALLLG RGRCLPARAP AVAEENPKES
   121  KPQAGTARPQ DVNRRDQQRN PGTSTTPSQP NSAGVQDTEM GPCRRHLDSV LQQLQTEVYR
   181  GAQTLYVPNC DHRGFYRKRQ CRSSQGQRRG PCWCVDRMGK SLPGSPDGNG SSSCPTGSSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGFBP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

787 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.92

gnomAD pLI

0.03

gnomAD missense Z

0.23

DepMap mean gene effect

-0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell migration
• negative regulation of canonical Wnt signaling pathway
• negative regulation of cell population proliferation
• positive regulation of MAPK cascade
• positive regulation of stress-activated MAPK cascade
• regulation of insulin-like growth factor receptor signaling pathway
• signal transduction

Molecular functions

• fibronectin binding
• identical protein binding
• insulin-like growth factor I binding
• insulin-like growth factor II binding
• signaling receptor binding

Cellular components

• extracellular region
• extracellular space
• insulin-like growth factor binary complex

Protein domainsUniProt · Pfam · InterPro

• Thyroglobulin type-1
• Insulin-like growth factor-binding protein, IGFBP
• Growth factor receptor cysteine-rich domain superfamily
• Insulin-like growth factor-binding protein family 1-6, chordata
• Thyroglobulin type-1 superfamily
• Thyroglobulin type-1 repeat
• Insulin-like growth factor-binding protein 6

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Growth factor binding
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IGFBP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PHB2