PHB1
Prohibitin 1
Also known as: PHB, PHB1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P35232
- Gene
- PHB1
- Ensembl
- ENSG00000167085
- Chromosome
- 17
- Canonical length
- 272 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Transporters
- Subcellular location
- Mitochondria
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Canonical amino-acid sequenceUniProt
272 residues, UniProt reviewed canonical sequence.
>P35232|PHB1
1 MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW
61 VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIFTSI GEDYDERVLP
121 SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT
181 EAVEAKQVAQ QEAERARFVV EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK
241 LEAAEDIAYQ LSRSRNITYL PAGQSVLLQL PQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PHB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 124 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 124 nTPM
- kidney: 117 nTPM
- skeletal muscle: 102 nTPM
- liver: 98 nTPM
- tongue: 92 nTPM
- heart muscle: 85 nTPM
Single-cell type
- esophageal basal cells: 373 nCPM
- salivary acinar cells: 356 nCPM
- migrating cytotrophoblasts: 343 nCPM
- esophageal suprabasal cells: 324 nCPM
- extravillous trophoblasts: 314 nCPM
- enteric transient amplifying cells: 314 nCPM
Immune cell
- plasmacytoid DC: 155 nTPM
- MAIT T-cell: 81 nTPM
- total PBMC: 80 nTPM
- NK-cell: 70 nTPM
- myeloid DC: 62 nTPM
- gdT-cell: 62 nTPM
Brain region
- choroid plexus: 57 nTPM
- white matter: 38 nTPM
- hypothalamus: 36 nTPM
- cerebellum: 36 nTPM
- medulla oblongata: 35 nTPM
- midbrain: 32 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about PHB1.
Disease | ImmuneIEDB
Conditions an epitope on PHB1 was assayed in.
- skin melanoma T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.47
- gnomAD pLI
- 0.76
- DepMap mean gene effect
- -1.89
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- antiviral innate immune response
- B cell activation
- cellular response to interleukin-6
- DNA biosynthetic process
- epigenetic regulation of gene expression
- host-mediated perturbation of viral RNA genome replication
- mitochondrion organization
- negative regulation of androgen receptor signaling pathway
- negative regulation of cell growth
- negative regulation of cell population proliferation
- negative regulation of DNA-templated transcription
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway
- negative regulation of protein catabolic process
- negative regulation of transcription by competitive promoter binding
- negative regulation of transcription by RNA polymerase II
- osteoblast differentiation
- positive regulation of complement activation
- positive regulation of DNA-templated transcription
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of G protein-coupled receptor signaling pathway
- positive regulation of gene expression
- positive regulation of immunoglobulin production
- positive regulation of interleukin-17 production
- positive regulation of neuron apoptotic process
- positive regulation of non-canonical NF-kappaB signal transduction
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- positive regulation of smooth muscle cell proliferation
- progesterone receptor signaling pathway
- protein stabilization
- regulation of apoptotic process
- regulation of DNA-templated transcription
- RIG-I signaling pathway
- signal transduction
- symbiont entry into host cell
- T-helper 17 type immune response
Molecular functions
- complement component C3b binding
- enzyme binding
- histone deacetylase binding
- protein heterodimerization activity
- proteinase activated receptor binding
- transcription corepressor activity
- complement component C3a binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PHB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PHB1 as an antibody target. Whether an autoantibody or antibody against PHB1 could matter depends on whether native PHB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PHB1 is annotated at the cell surface, where native PHB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PHB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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