Seroatlas · Human Serome Atlas

ITPRIP

Inositol 1,4,5-trisphosphate receptor-interacting protein

Also known as: bA127L20.2, DANGER, IPRI_HUMAN, KIAA1754

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWB1
Gene: ITPRIP
Ensembl: ENSG00000148841
Chromosome: 10
Canonical length: 547 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q8IWB1|ITPRIP
     1  MAMGLFRVCL VVVTAIINHP LLFPRENATV PENEEEIIRK MQAHQEKLQL EQLRLEEEVA
    61  RLAAEKEALE QVAEEGRQQN ETRVAWDLWS TLCMILFLMI EVWRQDHQEG PSPECLGGEE
   121  DELPGLGGAP LQGLTLPNKA TLGHFYERCI RGATADAART REFLEGFVDD LLEALRSLCN
   181  RDTDMEVEDF IGVDSMYENW QVDRPLLCHL FVPFTPPEPY RFHPELWCSG RSVPLDRQGY
   241  GQIKVVRADG DTLSCICGKT KLGEDMLCLL HGRNSMAPPC GDMENLLCAT DSLYLDTMQV
   301  MKWFQTALTR AWKGIAHKYE FDLAFGQLDS PGSLKIKFRS GKFMPFNLIP VIQCDDSDLY
   361  FVSHLPREPS EGTPASSTDW LLSFAVYERH FLRTTLKALP EGACHLSCLQ IASFLLSKQS
   421  RLTGPSGLSS YHLKTALLHL LLLRQAADWK AGQLDARLHE LLCFLEKSLL QKKLHHFFIG
   481  NRKVPEAMGL PEAVLRAEPL NLFRPFVLQR SLYRKTLDSF YEMLKNAPAL ISEYSLHVPS
   541  DQPTPKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITPRIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 192 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 192 nTPM
heart muscle: 69 nTPM
skin: 63 nTPM
esophagus: 50 nTPM
vagina: 42 nTPM
blood vessel: 41 nTPM

Single-cell type

neutrophils: 802 nCPM
esophageal apical cells: 239 nCPM
esophageal suprabasal cells: 237 nCPM
esophageal basal cells: 208 nCPM
neutrophil progenitors: 170 nCPM
suprabasal keratinocytes: 144 nCPM

Immune cell

neutrophil: 31 nTPM
total PBMC: 21 nTPM
eosinophil: 14 nTPM
classical monocyte: 9.5 nTPM
myeloid DC: 6.3 nTPM
non-classical monocyte: 5.9 nTPM

Brain region

choroid plexus: 27 nTPM
cerebral cortex: 18 nTPM
medulla oblongata: 12 nTPM
thalamus: 12 nTPM
white matter: 11 nTPM
spinal cord: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITPRIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ITPR
PGRMC2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITPRIP as an antibody target. Whether an autoantibody or antibody against ITPRIP could matter depends on whether native ITPRIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITPRIP is annotated at the cell surface, where native ITPRIP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ITPRIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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