Seroatlas · Human Serome Atlas

UTP14A

U3 small nucleolar RNA-associated protein 14 homolog A

Also known as: NY-CO-16, SDCCAG16, UT14A_HUMAN, Utp14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVJ6
Gene: UTP14A
Ensembl: ENSG00000156697
Chromosome: X
Canonical length: 771 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

771 residues, UniProt reviewed canonical sequence.

>Q9BVJ6|UTP14A
     1  MTANRLAESL LALSQQEELA DLPKDYLLSE SEDEGDNDGE RKHQKLLEAI SSLDGKNRRK
    61  LAERSEASLK VSEFNVSSEG SGEKLVLADL LEPVKTSSSL ATVKKQLSRV KSKKTVELPL
   121  NKEEIERIHR EVAFNKTAQV LSKWDPVVLK NRQAEQLVFP LEKEEPAIAP IEHVLSGWKA
   181  RTPLEQEIFN LLHKNKQPVT DPLLTPVEKA SLRAMSLEEA KMRRAELQRA RALQSYYEAK
   241  ARREKKIKSK KYHKVVKKGK AKKALKEFEQ LRKVNPAAAL EELEKIEKAR MMERMSLKHQ
   301  NSGKWAKSKA IMAKYDLEAR QAMQEQLSKN KELTQKLQVA SESEEEEGGT EDVEELLVPD
   361  VVNEVQMNAD GPNPWMLRSC TSDTKEAATQ EDPEQLPELE AHGVSESEGE ERPVAEEEIL
   421  LREFEERRSL RKRSELSQDA EPAGSQETKD SGSQEVLSEL RVLSQKLKEN HQSRKQKASS
   481  EGTIPQVQRE EPAPEEEEPL LLQRPERVQT LEELEELGKE ECFQNKELPR PVLEGQQSER
   541  TPNNRPDAPK EKKKKEQMID LQNLLTTQSP SVKSLAVPTI EELEDEEERN HRQMIKEAFA
   601  GDDVIRDFLK EKREAVEASK PKDVDLTLPG WGEWGGVGLK PSAKKRRRFL IKAPEGPPRK
   661  DKNLPNVIIN EKRNIHAAAH QVRVLPYPFT HHWQFERTIQ TPIGSTWNTQ RAFQKLTTPK
   721  VVTKPGHIIN PIKAEDVGYR SSSRSDLSVI QRNPKRITTR HKKQLKKCSV D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTP14A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

tonsil: 16 nTPM
pancreas: 15 nTPM
urinary bladder: 13 nTPM
lymph node: 13 nTPM
breast: 12 nTPM
ovary: 12 nTPM

Single-cell type

oocytes: 83 nCPM
syncytiotrophoblasts: 57 nCPM
erythrocyte progenitors: 48 nCPM
esophageal basal cells: 42 nCPM
pancreatic acinar cells: 38 nCPM
cytotrophoblasts: 35 nCPM

Immune cell

basophil: 29 nTPM
NK-cell: 19 nTPM
T-reg: 18 nTPM
intermediate monocyte: 17 nTPM
MAIT T-cell: 16 nTPM
non-classical monocyte: 15 nTPM

Brain region

basal ganglia: 13 nTPM
cerebral cortex: 13 nTPM
hypothalamus: 13 nTPM
thalamus: 12 nTPM
midbrain: 12 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 1.49
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

rRNA processing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UTP14A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTP14A as an antibody target. Whether an autoantibody or antibody against UTP14A could matter depends on whether native UTP14A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTP14A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UTP14A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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