Seroatlas · Human Serome Atlas

DSN1

Kinetochore-associated protein DSN1 homolog

Also known as: C20orf172, dJ469A13.2, DSN1_HUMAN, hKNL-3, KNL3, MIS13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H410
Gene
DSN1
Ensembl
ENSG00000149636
Chromosome
20
Canonical length
356 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Nuclear bodies,Kinetochore,Cytosol

OverviewNCBI Gene

This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>Q9H410|DSN1
     1  MTSVTRSEII DEKGPVMSKT HDHQLESSLS PVEVFAKTSA SLEMNQGVSE ERIHLGSSPK
    61  KGGNCDLSHQ ERLQSKSLHL SPQEQSASYQ DRRQSWRRAS MKETNRRKSL HPIHQGITEL
   121  SRSISVDLAE SKRLGCLLLS SFQFSIQKLE PFLRDTKGFS LESFRAKASS LSEELKHFAD
   181  GLETDGTLQK CFEDSNGKAS DFSLEASVAE MKEYITKFSL ERQTWDQLLL HYQQEAKEIL
   241  SRGSTEAKIT EVKVEPMTYL GSSQNEVLNT KPDYQKILQN QSKVFDCMEL VMDELQGSVK
   301  QLQAFMDEST QCFQKVSVQL GKRSMQQLDP SPARKLLKLQ LQNPPAIHGS GSGSCQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DSN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • testis: 22 nTPM
  • thymus: 15 nTPM
  • bone marrow: 14 nTPM
  • tonsil: 13 nTPM
  • lymph node: 12 nTPM
  • choroid plexus: 11 nTPM

Single-cell type

  • early primary spermatocytes: 148 nCPM
  • oocytes: 101 nCPM
  • syncytiotrophoblasts: 90 nCPM
  • cytotrophoblasts: 87 nCPM
  • differentiating spermatogonia: 81 nCPM
  • migrating cytotrophoblasts: 73 nCPM

Immune cell

  • basophil: 54 nTPM
  • plasmacytoid DC: 47 nTPM
  • naive B-cell: 19 nTPM
  • memory B-cell: 15 nTPM
  • eosinophil: 15 nTPM
  • T-reg: 12 nTPM

Brain region

  • choroid plexus: 7 nTPM
  • white matter: 5.6 nTPM
  • hypothalamus: 5.4 nTPM
  • cerebral cortex: 5 nTPM
  • amygdala: 4.8 nTPM
  • thalamus: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
-0.92
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Kinetochore-associated protein Dsn1/Mis13
  • Mis12-Mtw1 protein family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DSN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DSN1 as an antibody target. Whether an autoantibody or antibody against DSN1 could matter depends on whether native DSN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DSN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DSN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DSN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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