Seroatlas · Human Serome Atlas

SPC24

Kinetochore protein Spc24

Also known as: FLJ90806, SPBC24, SPC24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBT2
Gene: SPC24
Ensembl: ENSG00000161888
Chromosome: 19
Canonical length: 197 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to contribute to microtubule binding activity. Involved in attachment of spindle microtubules to kinetochore. Located in kinetochore; nucleolus; and nucleoplasm. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q8NBT2|SPC24
     1  MAAFRDIEEV SQGLLSLLGA NRAEAQQRRL LGRHEQVVER LLETQDGAEK QLREILTMEK
    61  EVAQSLLNAK EQVHQGGVEL QQLEAGLQEA GEEDTRLKAS LLQLTRELEE LKEIEADLER
   121  QEKEVDEDTT VTIPSAVYVA QLYHQVSKIE WDYECEPGMV KGIHHGPSVA QPIHLDSTQL
   181  SRKFISDYLW SLVDTEW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPC24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 24 nTPM
thymus: 14 nTPM
smooth muscle: 7.5 nTPM
tonsil: 6.1 nTPM
lymph node: 5.8 nTPM
esophagus: 4.7 nTPM

Single-cell type

epicardial cells: 134 nCPM
erythrocyte progenitors: 49 nCPM
monocyte progenitors: 40 nCPM
megakaryocyte progenitors: 31 nCPM
hofbauer cells: 29 nCPM
differentiating spermatogonia: 24 nCPM

Immune cell

neutrophil: 2.1 nTPM
basophil: 2 nTPM
NK-cell: 2 nTPM
T-reg: 1.7 nTPM
memory CD8 T-cell: 1.4 nTPM
memory CD4 T-cell: 0.8 nTPM

Brain region

cerebellum: 13 nTPM
cerebral cortex: 9.2 nTPM
white matter: 9 nTPM
choroid plexus: 8.9 nTPM
hippocampal formation: 8.3 nTPM
hypothalamus: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: -2.09
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Kinetochore-Ndc80 subunit Spc24
Spc24 subunit of Ndc80

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPC24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPC24 as an antibody target. Whether an autoantibody or antibody against SPC24 could matter depends on whether native SPC24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPC24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPC24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...