Seroatlas · Human Serome Atlas

FRS2

Fibroblast growth factor receptor substrate 2

Also known as: FRS2_HUMAN, FRS2A, FRS2alpha, SNT-1, SNT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WU20
Gene
FRS2
Ensembl
ENSG00000166225
Chromosome
12
Canonical length
508 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cell Junctions

OverviewNCBI Gene

Enables fibroblast growth factor receptor binding activity and neurotrophin TRKA receptor binding activity. Involved in negative regulation of cardiac muscle cell differentiation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in adherens junction. Biomarker of renal cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q8WU20|FRS2
     1  MGSCCSCPDK DTVPDNHRNK FKVINVDDDG NELGSGIMEL TDTELILYTR KRDSVKWHYL
    61  CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CARAEELFNM LQEIMQNNSI NVVEEPVVER
   121  NNHQTELEVP RTPRTPTTPG FAAQNLPNGY PRYPSFGDAS SHPSSRHPSV GSARLPSVGE
   181  ESTHPLLVAE EQVHTYVNTT GVQEERKNRT SVHVPLEARV SNAESSTPKE EPSSIEDRDP
   241  QILLEPEGVK FVLGPTPVQK QLMEKEKLEQ LGRDQVSGSG ANNTEWDTGY DSDERRDAPS
   301  VNKLVYENIN GLSIPSASGV RRGRLTSTST SDTQNINNSA QRRTALLNYE NLPSLPPVWE
   361  ARKLSRDEDD NLGPKTPSLN GYHNNLDPMH NYVNTENVTV PASAHKIEYS RRRDCTPTVF
   421  NFDIRRPSLE HRQLNYIQVD LEGGSDSDNP QTPKTPTTPL PQTPTRRTEL YAVIDIERTA
   481  AMSNLQKALP RDDGTSRKTR HNSTDLPM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 26 nTPM
  • ovary: 14 nTPM
  • epididymis: 13 nTPM
  • breast: 12 nTPM
  • cerebral cortex: 12 nTPM
  • thyroid gland: 12 nTPM

Single-cell type

  • cardiomyocytes: 283 nCPM
  • bergmann glia: 248 nCPM
  • myonuclei: 196 nCPM
  • pituicytes/fscs: 183 nCPM
  • astrocytes: 182 nCPM
  • gonadotrophs: 181 nCPM

Immune cell

  • non-classical monocyte: 7.5 nTPM
  • naive B-cell: 6.1 nTPM
  • naive CD4 T-cell: 5 nTPM
  • neutrophil: 4.3 nTPM
  • classical monocyte: 4.2 nTPM
  • intermediate monocyte: 3.8 nTPM

Brain region

  • white matter: 80 nTPM
  • cerebellum: 72 nTPM
  • spinal cord: 67 nTPM
  • basal ganglia: 62 nTPM
  • hypothalamus: 60 nTPM
  • cerebral cortex: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
1.13
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FRS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRS2 as an antibody target. Whether an autoantibody or antibody against FRS2 could matter depends on whether native FRS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRS2 is annotated at the cell surface, where native FRS2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FRS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FRS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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