SLITRK2

Protein identityUniProt · HPA

UniProt accession

Q9H156

Gene

SLITRK2

Ensembl

ENSG00000185985

Chromosome

X

Canonical length

845 aa

Protein class

Predicted membrane proteins

OverviewNCBI Gene

This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.[provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

845 residues, UniProt reviewed canonical sequence.

>Q9H156|SLITRK2
     1  MLSGVWFLSV LTVAGILQTE SRKTAKDICK IRCLCEEKEN VLNINCENKG FTTVSLLQPP
    61  QYRIYQLFLN GNLLTRLYPN EFVNYSNAVT LHLGNNGLQE IRTGAFSGLK TLKRLHLNNN
   121  KLEILREDTF LGLESLEYLQ ADYNYISAIE AGAFSKLNKL KVLILNDNLL LSLPSNVFRF
   181  VLLTHLDLRG NRLKVMPFAG VLEHIGGIME IQLEENPWNC TCDLLPLKAW LDTITVFVGE
   241  IVCETPFRLH GKDVTQLTRQ DLCPRKSASD SSQRGSHADT HVQRLSPTMN PALNPTRAPK
   301  ASRPPKMRNR PTPRVTVSKD RQSFGPIMVY QTKSPVPLTC PSSCVCTSQS SDNGLNVNCQ
   361  ERKFTNISDL QPKPTSPKKL YLTGNYLQTV YKNDLLEYSS LDLLHLGNNR IAVIQEGAFT
   421  NLTSLRRLYL NGNYLEVLYP SMFDGLQSLQ YLYLEYNVIK EIKPLTFDAL INLQLLFLNN
   481  NLLRSLPDNI FGGTALTRLN LRNNHFSHLP VKGVLDQLPA FIQIDLQENP WDCTCDIMGL
   541  KDWTEHANSP VIINEVTCES PAKHAGEILK FLGREAICPD SPNLSDGTVL SMNHNTDTPR
   601  SLSVSPSSYP ELHTEVPLSV LILGLLVVFI LSVCFGAGLF VFVLKRRKGV PSVPRNTNNL
   661  DVSSFQLQYG SYNTETHDKT DGHVYNYIPP PVGQMCQNPI YMQKEGDPVA YYRNLQEFSY
   721  SNLEEKKEEP ATPAYTISAT ELLEKQATPR EPELLYQNIA ERVKELPSAG LVHYNFCTLP
   781  KRQFAPSYES RRQNQDRINK TVLYGTPRKC FVGQSKPNHP LLQAKPQSEP DYLEVLEKQT
   841  AISQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLITRK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

30 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLITRK2.

Disease | AllUniProt

Conditions SLITRK2 is implicated in, by any mechanism.

• Intellectual developmental disorder, X-linked 111 (XLID111) MIM:301107

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 144 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Intellectual disability
• Intellectual developmental disorder, X-linked 111

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.69

gnomAD pLI

0.01

gnomAD missense Z

2.2

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axonogenesis
• positive regulation of synapse assembly
• regulation of presynapse assembly
• regulation of synapse organization
• synaptic membrane adhesion

Cellular components

• dendrite
• GABA-ergic synapse
• glutamatergic synapse
• plasma membrane
• postsynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat N-terminal domain
• Cysteine-rich flanking region, C-terminal
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Leucine-rich repeat domain superfamily
• Leucine rich repeat

KeywordsUniProt

• Cell membrane
• Cell projection
• Disulfide bond
• Glycoprotein
• Intellectual disability
• Leucine-rich repeat
• Membrane
• Phosphoprotein
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of SLITRK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NTRK2
• PTPRD