Seroatlas · Human Serome Atlas

NOLC1

Nucleolar and coiled-body phosphoprotein 1

Also known as: KIAA0035, NOLC1_HUMAN, NOPP130, NOPP140, P130, Srp40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14978
Gene: NOLC1
Ensembl: ENSG00000166197
Chromosome: 10
Canonical length: 699 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

Enables molecular function inhibitor activity; protein heterodimerization activity; and protein-macromolecule adaptor activity. Involved in neural crest cell development; neural crest formation; and regulation of translation. Acts upstream of or within axonogenesis and regulation of synaptic plasticity. Located in fibrillar center. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

699 residues, UniProt reviewed canonical sequence.

>Q14978|NOLC1
     1  MADAGIRRVV PSDLYPLVLG FLRDNQLSEV ANKFAKATGA TQQDANASSL LDIYSFWLKS
    61  AKVPERKLQA NGPVAKKAKK KASSSDSEDS SEEEEEVQGP PAKKAAVPAK RVGLPPGKAA
   121  AKASESSSSE ESSDDDDEED QKKQPVQKGV KPQAKAAKAP PKKAKSSDSD SDSSSEDEPP
   181  KNQKPKITPV TVKAQTKAPP KPARAAPKIA NGKAASSSSS SSSSSSSDDS EEEKAAATPK
   241  KTVPKKQVVA KAPVKAATTP TRKSSSSEDS SSDEEEEQKK PMKNKPGPYS SVPPPSAPPP
   301  KKSLGTQPPK KAVEKQQPVE SSEDSSDESD SSSEEEKKPP TKAVVSKATT KPPPAKKAAE
   361  SSSDSSDSDS SEDDEAPSKP AGTTKNSSNK PAVTTKSPAV KPAAAPKQPV GGGQKLLTRK
   421  ADSSSSEEES SSSEEEKTKK MVATTKPKAT AKAALSLPAK QAPQGSRDSS SDSDSSSSEE
   481  EEEKTSKSAV KKKPQKVAGG AAPSKPASAK KGKAESSNSS SSDDSSEEEE EKLKGKGSPR
   541  PQAPKANGTS ALTAQNGKAA KNSEEEEEEK KKAAVVVSKS GSLKKRKQNE AAKEAETPQA
   601  KKIKLQTPNT FPKRKKGEKR ASSPFRRVRE EEIEVDSRVA DNSFDAKRGA AGDWGERANQ
   661  VLKFTKGKSF RHEKTKKKRG SYRGGSISVQ VNSIKFDSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOLC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 60 nTPM
tonsil: 52 nTPM
thymus: 51 nTPM
skeletal muscle: 48 nTPM
tongue: 43 nTPM
parathyroid gland: 40 nTPM

Single-cell type

basal keratinocytes: 133 nCPM
suprabasal keratinocytes: 122 nCPM
erythrocyte progenitors: 116 nCPM
esophageal basal cells: 115 nCPM
ocular epithelial cells: 112 nCPM
migrating cytotrophoblasts: 87 nCPM

Immune cell

MAIT T-cell: 25 nTPM
naive CD8 T-cell: 23 nTPM
gdT-cell: 20 nTPM
memory CD8 T-cell: 19 nTPM
naive CD4 T-cell: 19 nTPM
total PBMC: 18 nTPM

Brain region

cerebral cortex: 65 nTPM
hypothalamus: 51 nTPM
white matter: 50 nTPM
midbrain: 44 nTPM
cerebellum: 44 nTPM
pons: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: -1
DepMap mean gene effect: -0.49
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

LIS1 homology motif
Srp40, C-terminal
Nopp140-like
SRP40, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOLC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOLC1 as an antibody target. Whether an autoantibody or antibody against NOLC1 could matter depends on whether native NOLC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOLC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOLC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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