Myosin tail
IPR002928
Definition
Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains PMID:1939027, 2 alkali light chains, and 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail PMID:11919279, although some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains, coded for by a multi-gene family PMID:2806546. Myosin interacts with actin to convert chemical energy, in the form of ATP, to mechanical energy PMID:3540939. The 3-D structure of the head portion of myosin has been determined PMID:8316857 and a model for actin-myosin complex has been constructed PMID:8316858. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament [[cite:PMID:3783701], [cite:PMID:26150528]]. It contains skip residues that confers local relaxation surrounding them and allows the transition of the coiled-coil to a nonclose-packed structure PMID:26150528. The coiled-coil region provides the structural backbone of the thick filament [[cite:PMID:3783701], [cite:PMID:26150528]].
19 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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