Seroatlas · Human Serome Atlas

CFAP95

Cilia- and flagella-associated protein 95

Also known as: C9orf135, CFA95_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VTT2
Gene: CFAP95
Ensembl: ENSG00000204711
Chromosome: 9
Canonical length: 229 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mid piece,Principal piece

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q5VTT2|CFAP95
     1  MDSLDRSCQD WCDRKQHWLE IGPPDLVERK GSLTLRSHHK KYSKPVLVYS WHRDREAFPK
    61  GYDIEGPEKV KKLCNSTYRR LGTDESPIWT SETHEKLSQM CLNTEWVEMK SKALLNEETV
   121  SSGIIERVTG LPATGFGAVF PRHPPDWSKM CALTTYSEDY VPPYDYQPHA YPCQDDYSIV
   181  HRKCRSQFTD LNGSKRFGIN TWHDESGIYA NSDVKQKLYP LTSGPIVPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP95 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 35 nTPM
choroid plexus: 28 nTPM
testis: 15 nTPM
pituitary gland: 7.2 nTPM
parathyroid gland: 2.8 nTPM
lung: 2.1 nTPM

Single-cell type

fallopian tube ciliated cells: 535 nCPM
respiratory ciliated cells: 505 nCPM
endometrial ciliated cells: 268 nCPM
epididymal efferent duct ciliated cells: 251 nCPM
late primary spermatocytes: 236 nCPM
early spermatids: 137 nCPM

Immune cell

naive CD8 T-cell: 1.7 nTPM
T-reg: 1.5 nTPM
naive CD4 T-cell: 1.2 nTPM
memory CD4 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 14 nTPM
midbrain: 5.1 nTPM
spinal cord: 3.7 nTPM
medulla oblongata: 3.4 nTPM
hypothalamus: 2.1 nTPM
pons: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cilia- and flagella-associated protein 95
Protein CFAP95

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP95 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP95 as an antibody target. Whether an autoantibody or antibody against CFAP95 could matter depends on whether native CFAP95 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP95 is annotated at the cell surface, where native CFAP95 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CFAP95 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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