MRFAP1
MORF4 family-associated protein 1
Also known as: MOFA1_HUMAN, PAM14, PGR1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y605
- Gene
- MRFAP1
- Ensembl
- ENSG00000179010
- Chromosome
- 4
- Canonical length
- 127 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Canonical amino-acid sequenceUniProt
127 residues, UniProt reviewed canonical sequence.
>Q9Y605|MRFAP1
1 MRPLDIVELA EPEEVEVLEP EEDFEQFLLP VINEMREDIA SLTREHGRAY LRNRSKLWEM
61 DNMLIQIKTQ VEASEESALN HLQNPGDAAE GRAAKRCEKA EEKAKEIAKM AEMLVELVRR
121 IEKSESSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MRFAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 490 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 490 nTPM
- midbrain: 436 nTPM
- amygdala: 419 nTPM
- hypothalamus: 406 nTPM
- choroid plexus: 403 nTPM
- cerebral cortex: 396 nTPM
Single-cell type
- cytotrophoblasts: 657 nCPM
- migrating cytotrophoblasts: 526 nCPM
- esophageal apical cells: 477 nCPM
- esophageal suprabasal cells: 443 nCPM
- esophageal basal cells: 403 nCPM
- oocytes: 364 nCPM
Immune cell
- basophil: 203 nTPM
- neutrophil: 200 nTPM
- total PBMC: 196 nTPM
- classical monocyte: 186 nTPM
- myeloid DC: 178 nTPM
- eosinophil: 164 nTPM
Brain region
- medulla oblongata: 415 nTPM
- white matter: 355 nTPM
- cerebral cortex: 346 nTPM
- pons: 321 nTPM
- midbrain: 319 nTPM
- hypothalamus: 311 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.14
- gnomAD pLI
- 0.31
- gnomAD missense Z
- 0.17
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MRFAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MRFAP1 as an antibody target. Whether an autoantibody or antibody against MRFAP1 could matter depends on whether native MRFAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MRFAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MRFAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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