MOB kinase activator superfamily

Definition

The MOB kinase activator superfamily includes MOB1, an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature PMID:9436989. This superfamily also includes the MOB-like protein phocein, an intracellular protein that interacts with striatin and may play a role in membrane trafficking PMID:11872741. Structurally, domains in this superfamily have a bromodomain-like fold, which consists of four helices arranged as a bundle with a minor mirror variant of up-and-down topology; they also contain a zinc-binding site.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• MOB1A
• MOB1B
• MOB2
• MOB3A
• MOB3B
• MOB3C
• MOB4