NDUFA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Also known as: B9, NDUA3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95167
- Gene
- NDUFA3
- Ensembl
- ENSG00000170906
- Chromosome
- 19
- Canonical length
- 84 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
OverviewNCBI Gene
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrial inner membrane. Part of respiratory chain complex I. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
84 residues, UniProt reviewed canonical sequence.
>O95167|NDUFA3
1 MAARVGAFLK NAWDKEPVLV VSFVVGGLAV ILPPLSPYFK YSVMINKATP YNYPVPVRDD
61 GNMPDVPSHP QDPQGPSLEW LKKLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NDUFA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 603 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 603 nTPM
- skeletal muscle: 490 nTPM
- basal ganglia: 416 nTPM
- amygdala: 402 nTPM
- midbrain: 368 nTPM
- hippocampal formation: 355 nTPM
Single-cell type
- late spermatids: 3,263 nCPM
- parietal cells: 1,215 nCPM
- late primary spermatocytes: 619 nCPM
- enterocytes: 580 nCPM
- hepatocytes: 536 nCPM
- gastric chief cells: 489 nCPM
Immune cell
- plasmacytoid DC: 24 nTPM
- basophil: 23 nTPM
- total PBMC: 22 nTPM
- eosinophil: 20 nTPM
- memory B-cell: 18 nTPM
- NK-cell: 17 nTPM
Brain region
- cerebellum: 39 nTPM
- white matter: 36 nTPM
- cerebral cortex: 34 nTPM
- thalamus: 32 nTPM
- medulla oblongata: 29 nTPM
- hypothalamus: 28 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.47
- gnomAD pLI
- 0.07
- gnomAD missense Z
- -0.39
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- aerobic respiration
- mitochondrial electron transport, NADH to ubiquinone
- proton motive force-driven mitochondrial ATP synthesis
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
- NADH dehydrogenase 1 alpha subcomplex subunit 3
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NDUFA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NDUFA3 as an antibody target. Whether an autoantibody or antibody against NDUFA3 could matter depends on whether native NDUFA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NDUFA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NDUFA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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