Seroatlas · Human Serome Atlas

CORO1C

Coronin-1C

Also known as: COR1C_HUMAN, coronin-3, HCRNN4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULV4
Gene
CORO1C
Ensembl
ENSG00000110880
Chromosome
12
Canonical length
474 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>Q9ULV4|CORO1C
     1  MRRVVRQSKF RHVFGQAVKN DQCYDDIRVS RVTWDSSFCA VNPRFVAIII EASGGGAFLV
    61  LPLHKTGRID KSYPTVCGHT GPVLDIDWCP HNDQVIASGS EDCTVMVWQI PENGLTLSLT
   121  EPVVILEGHS KRVGIVAWHP TARNVLLSAG CDNAIIIWNV GTGEALINLD DMHSDMIYNV
   181  SWNRNGSLIC TASKDKKVRV IDPRKQEIVA EKEKAHEGAR PMRAIFLADG NVFTTGFSRM
   241  SERQLALWNP KNMQEPIALH EMDTSNGVLL PFYDPDTSII YLCGKGDSSI RYFEITDESP
   301  YVHYLNTFSS KEPQRGMGYM PKRGLDVNKC EIARFFKLHE RKCEPIIMTV PRKSDLFQDD
   361  LYPDTAGPEA ALEAEEWFEG KNADPILISL KHGYIPGKNR DLKVVKKNIL DSKPTANKKC
   421  DLISIPKKTT DTASVQNEAK LDEILKEIKS IKDTICNQDE RISKLEQQMA KIAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CORO1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
133 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 133 nTPM
  • blood vessel: 118 nTPM
  • colon: 112 nTPM
  • endometrium: 90 nTPM
  • lung: 72 nTPM
  • urinary bladder: 69 nTPM

Single-cell type

  • platelets: 541 nCPM
  • pdcs: 320 nCPM
  • ocular epithelial cells: 264 nCPM
  • suprabasal keratinocytes: 262 nCPM
  • basal keratinocytes: 248 nCPM
  • megakaryocytes: 247 nCPM

Immune cell

  • neutrophil: 83 nTPM
  • intermediate monocyte: 78 nTPM
  • plasmacytoid DC: 76 nTPM
  • myeloid DC: 76 nTPM
  • non-classical monocyte: 76 nTPM
  • classical monocyte: 71 nTPM

Brain region

  • white matter: 100 nTPM
  • medulla oblongata: 82 nTPM
  • thalamus: 77 nTPM
  • hippocampal formation: 75 nTPM
  • hypothalamus: 72 nTPM
  • spinal cord: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
2.33
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CORO1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CORO1C as an antibody target. Whether an autoantibody or antibody against CORO1C could matter depends on whether native CORO1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CORO1C is annotated at the cell surface, where native CORO1C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CORO1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CORO1C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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