Seroatlas · Human Serome Atlas

IFNAR2

Interferon alpha/beta receptor 2

Also known as: IFNABR, INAR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48551
Gene
IFNAR2
Ensembl
ENSG00000159110
Chromosome
21
Canonical length
515 aa
Protein class
Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>P48551|IFNAR2
     1  MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS
    61  IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF
   121  SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK
   181  HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE
   241  SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD
   301  MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA SATSTESQLI
   361  DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS PLQDPFPEED YSSTEGSGGR
   421  ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS SHLEEMVDPE DPDNVQSNHL LASGEGTQPT
   481  FPSPSSEGLW SEDAPSDQSD TSESDVDLGD GYIMR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFNAR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 33 nTPM
  • urinary bladder: 30 nTPM
  • tonsil: 29 nTPM
  • lymph node: 27 nTPM
  • thymus: 25 nTPM
  • appendix: 25 nTPM

Single-cell type

  • plasma cells: 73 nCPM
  • extravillous trophoblasts: 67 nCPM
  • oligodendrocyte progenitor cells: 51 nCPM
  • microglia: 47 nCPM
  • brain inhibitory neurons: 40 nCPM
  • oligodendrocytes: 39 nCPM

Immune cell

  • plasmacytoid DC: 90 nTPM
  • neutrophil: 87 nTPM
  • T-reg: 60 nTPM
  • eosinophil: 54 nTPM
  • non-classical monocyte: 52 nTPM
  • intermediate monocyte: 49 nTPM

Brain region

  • medulla oblongata: 29 nTPM
  • thalamus: 28 nTPM
  • pons: 26 nTPM
  • hypothalamus: 25 nTPM
  • midbrain: 24 nTPM
  • spinal cord: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFNAR2.

Disease | AllUniProt

Conditions IFNAR2 is implicated in, by any mechanism.

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 339 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.26
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFNAR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFNAR2 as an antibody target. Whether an autoantibody or antibody against IFNAR2 could matter depends on whether native IFNAR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFNAR2 is annotated at the cell surface, where native IFNAR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IFNAR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFNAR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...