Seroatlas · Human Serome Atlas

BATF

Basic leucine zipper transcriptional factor ATF-like

Also known as: B-ATF, BATF_HUMAN, BATF1, SFA-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16520
Gene: BATF
Ensembl: ENSG00000156127
Chromosome: 14
Canonical length: 125 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q16520|BATF
     1  MPHSSDSSDS SFSRSPPPGK QDSSDDVRRV QRREKNRIAA QKSRQRQTQK ADTLHLESED
    61  LEKQNAALRK EIKQLTEELK YFTSVLNSHE PLCSVLAAST PSPPEVVYSA HAFHQPHVSS
   121  PRFQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BATF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

lymph node: 29 nTPM
spleen: 28 nTPM
bone marrow: 21 nTPM
appendix: 19 nTPM
tonsil: 19 nTPM
urinary bladder: 17 nTPM

Single-cell type

mast cells: 640 nCPM
breast hormone-responsive cells: 344 nCPM
t-cells: 174 nCPM
urothelial cells: 151 nCPM
hofbauer cells: 120 nCPM
neutrophils: 111 nCPM

Immune cell

T-reg: 131 nTPM
memory CD8 T-cell: 74 nTPM
memory CD4 T-cell: 60 nTPM
gdT-cell: 55 nTPM
naive CD8 T-cell: 51 nTPM
MAIT T-cell: 44 nTPM

Brain region

thalamus: 2.8 nTPM
basal ganglia: 2.1 nTPM
pons: 1.9 nTPM
medulla oblongata: 1.3 nTPM
white matter: 1.3 nTPM
midbrain: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.85
gnomAD missense Z: 1.61
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BATF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BATF as an antibody target. Whether an autoantibody or antibody against BATF could matter depends on whether native BATF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BATF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BATF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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