Seroatlas · Human Serome Atlas

BATF2

Basic leucine zipper transcriptional factor ATF-like 2

Also known as: BATF2_HUMAN, MGC20410

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1L9
Gene: BATF2
Ensembl: ENSG00000168062
Chromosome: 11
Canonical length: 274 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to protozoan; myeloid dendritic cell differentiation; and regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

274 residues, UniProt reviewed canonical sequence.

>Q8N1L9|BATF2
     1  MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE SLEKDNLALR
    61  KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW DQAEGLLGPG PQGQHGCREQ
   121  LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ CPLPSLSLGP AVVAEPPVQL SPSPLLFASH
   181  TGSSLQGSSS KLSALQPSLT AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH
   241  KPALSAATWQ GLVVDPSPHP LLAFPLLSSA QVHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BATF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

spleen: 13 nTPM
salivary gland: 13 nTPM
pancreas: 9.2 nTPM
duodenum: 8.8 nTPM
appendix: 8.2 nTPM
colon: 8.1 nTPM

Single-cell type

colonocytes: 21 nCPM
enterocytes: 18 nCPM
goblet cells: 17 nCPM
pancreatic acinar cells: 13 nCPM
breast lactating cells: 13 nCPM
enteric stem cells: 12 nCPM

Immune cell

neutrophil: 7.4 nTPM
intermediate monocyte: 5.3 nTPM
non-classical monocyte: 2.8 nTPM
classical monocyte: 2.1 nTPM
eosinophil: 1 nTPM
memory B-cell: 1 nTPM

Brain region

medulla oblongata: 5.3 nTPM
pons: 4.9 nTPM
spinal cord: 4.8 nTPM
thalamus: 3 nTPM
basal ganglia: 2.5 nTPM
choroid plexus: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0.59
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BATF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

JUNB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BATF2 as an antibody target. Whether an autoantibody or antibody against BATF2 could matter depends on whether native BATF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BATF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BATF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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