Seroatlas · Human Serome Atlas

INTS11

Integrator complex subunit 11

Also known as: CPSF3L, CPSF73L, FLJ20542, INT11, INT11_HUMAN, RC-68

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5TA45
Gene
INTS11
Ensembl
ENSG00000127054
Chromosome
1
Canonical length
600 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

600 residues, UniProt reviewed canonical sequence.

>Q5TA45|INTS11
     1  MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDRRFPDFSY ITQNGRLTDF
    61  LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC PILLEDYRKI AVDKKGEANF
   121  FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN
   181  MTPDRHLGAA WIDKCRPNLL ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF
   241  ALGRAQELCI LLETFWERMN LKVPIYFSTG LTEKANHYYK LFIPWTNQKI RKTFVQRNMF
   301  EFKHIKAFDR AFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM PGYCVQGTVG
   361  HKILSGQRKL EMEGRQVLEV KMQVEYMSFS AHADAKGIMQ LVGQAEPESV LLVHGEAKKM
   421  EFLKQKIEQE LRVNCYMPAN GETVTLPTSP SIPVGISLGL LKREMAQGLL PEAKKPRLLH
   481  GTLIMKDSNF RLVSSEQALK ELGLAEHQLR FTCRVHLHDT RKEQETALRV YSHLKSVLKD
   541  HCVQHLPDGS VTVESVLLQA AAPSEDPGTK VLLVSWTYQD EELGSFLTSL LKKGLPQAPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
88 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 88 nTPM
  • testis: 75 nTPM
  • cerebellum: 70 nTPM
  • endometrium: 70 nTPM
  • colon: 69 nTPM
  • blood vessel: 69 nTPM

Single-cell type

  • late spermatids: 559 nCPM
  • late primary spermatocytes: 196 nCPM
  • early spermatids: 165 nCPM
  • decidual stromal cells: 103 nCPM
  • early primary spermatocytes: 94 nCPM
  • syncytiotrophoblasts: 93 nCPM

Immune cell

  • non-classical monocyte: 101 nTPM
  • intermediate monocyte: 82 nTPM
  • myeloid DC: 81 nTPM
  • total PBMC: 81 nTPM
  • T-reg: 78 nTPM
  • classical monocyte: 69 nTPM

Brain region

  • cerebellum: 58 nTPM
  • cerebral cortex: 50 nTPM
  • white matter: 49 nTPM
  • pons: 45 nTPM
  • basal ganglia: 40 nTPM
  • medulla oblongata: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about INTS11.

Disease | AllUniProt

Conditions INTS11 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities (NEDMLOB) MIM:620428

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 188 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
DepMap mean gene effect
-1.93
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS11 as an antibody target. Whether an autoantibody or antibody against INTS11 could matter depends on whether native INTS11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INTS11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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