Seroatlas · Human Serome Atlas

INTS5

Integrator complex subunit 5

Also known as: INT5, INT5_HUMAN, KIAA1698

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P9B9
Gene
INTS5
Ensembl
ENSG00000185085
Chromosome
11
Canonical length
1019 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

1019 residues, UniProt reviewed canonical sequence.

>Q6P9B9|INTS5
     1  MSALCDPPGA PGPPGPAPAT HGPAPLSAQE LSQEIKAFLT GVDPILGHQL SAREHARCGL
    61  LLLRSLPPAR AAVLDHLRGV FDESVRAHLA ALDETPVAGP PHLRPPPPSH VPAGGPGLED
   121  VVQEVQQVLS EFIRANPKAW APVISAWSID LMGQLSSTYS GQHQRVPHAT GALNELLQLW
   181  MGCRATRTLM DIYVQCLSAL IGSCPDACVD ALLDTSVQHS PHFDWVVAHI GSSFPGTIIS
   241  RVLSCGLKDF CVHGGAGGGA GSSGGSSSQT PSTDPFPGSP AIPAEKRVPK IASVVGILGH
   301  LASRHGDSIR RELLRMFHDS LAGGSGGRSG DPSLQATVPF LLQLAVMSPA LLGTVSGELV
   361  DCLKPPAVLS QLQQHLQGFP REELDNMLNL AVHLVSQASG AGAYRLLQFL VDTAMPASVI
   421  TTQGLAVPDT VREACDRLIQ LLLLHLQKLV HHRGGSPGEG VLGPPPPPRL VPFLDALKNH
   481  VGELCGETLR LERKRFLWQH QLLGLLSVYT RPSCGPEALG HLLSRARSPE ELSLATQLYA
   541  GLVVSLSGLL PLAFRSCLAR VHAGTLQPPF TARFLRNLAL LVGWEQQGGE GPAALGAHFG
   601  ESASAHLSDL APLLLHPEEE VAEAAASLLA ICPFPSEALS PSQLLGLVRA GVHRFFASLR
   661  LHGPPGVASA CQLLTRLSQT SPAGLKAVLQ LLVEGALHRG NTELFGGQVD GDNETLSVVS
   721  ASLASASLLD TNRRHTAAVP GPGGIWSVFH AGVIGRGLKP PKFVQSRNQQ EVIYNTQSLL
   781  SLLVHCCSAP GGTECGECWG APILSPEAAK AVAVTLVESV CPDAAGAELA WPPEEHARAT
   841  VERDLRIGRR FREQPLLFEL LKLVAAAPPA LCYCSVLLRG LLAALLGHWE ASRHPDTTHS
   901  PWHLEASCTL VAVMAEGSLL PPALGNMHEV FSQLAPFEVR LLLLSVWGFL REHGPLPQKF
   961  IFQSERGRFI RDFSREGGGE GGPHLAVLHS VLHRNIDRLG LFSGRFQAPS PSTLLRQGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 13 nTPM
  • fallopian tube: 12 nTPM
  • liver: 12 nTPM
  • skin: 12 nTPM
  • esophagus: 12 nTPM
  • salivary gland: 11 nTPM

Single-cell type

  • syncytiotrophoblasts: 26 nCPM
  • megakaryocytes: 19 nCPM
  • decidual stromal cells: 18 nCPM
  • respiratory ciliated cells: 17 nCPM
  • cytotrophoblasts: 16 nCPM
  • paneth cells: 16 nCPM

Immune cell

  • MAIT T-cell: 10 nTPM
  • NK-cell: 7.8 nTPM
  • naive CD4 T-cell: 6.9 nTPM
  • naive CD8 T-cell: 6.5 nTPM
  • gdT-cell: 6.4 nTPM
  • total PBMC: 6.3 nTPM

Brain region

  • medulla oblongata: 13 nTPM
  • thalamus: 13 nTPM
  • cerebral cortex: 12 nTPM
  • midbrain: 12 nTPM
  • pons: 12 nTPM
  • cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.51
gnomAD missense Z
1.73
DepMap mean gene effect
-1.04
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Integrator complex subunit 5, C-terminal
  • Integrator complex subunit 5, N-terminal
  • Integrator complex subunit 5
  • Integrator complex subunit 5 N-terminus
  • Integrator complex subunit 5 C-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS5 as an antibody target. Whether an autoantibody or antibody against INTS5 could matter depends on whether native INTS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INTS5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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