Seroatlas · Human Serome Atlas

INTS4

Integrator complex subunit 4

Also known as: INT4, INT4_HUMAN, MGC16733, MST093

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96HW7
Gene
INTS4
Ensembl
ENSG00000149262
Chromosome
11
Canonical length
963 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli rim

OverviewNCBI Gene

INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

963 residues, UniProt reviewed canonical sequence.

>Q96HW7|INTS4
     1  MAAHLKKRVY EEFTKVVQPQ EEIATKKLRL TKPSKSAALH IDLCKATSPA DALQYLLQFA
    61  RKPVEAESVE GVVRILLEHY YKENDPSVRL KIASLLGLLS KTAGFSPDCI MDDAINILQN
   121  EKSHQVLAQL LDTLLAIGTK LPENQAIQMR LVDVACKHLT DTSHGVRNKC LQLLGNLGSL
   181  EKSVTKDAEG LAARDVQKII GDYFSDQDPR VRTAAIKAML QLHERGLKLH QTIYNQACKL
   241  LSDDYEQVRS AAVQLIWVVS QLYPESIVPI PSSNEEIRLV DDAFGKICHM VSDGSWVVRV
   301  QAAKLLGSME QVSSHFLEQT LDKKLMSDLR RKRTAHERAK ELYSSGEFSS GRKWGDDAPK
   361  EEVDTGAVNL IESGACGAFV HGLEDEMYEV RIAAVEALCM LAQSSPSFAE KCLDFLVDMF
   421  NDEIEEVRLQ SIHTMRKISN NITLREDQLD TVLAVLEDSS RDIREALHEL LCCTNVSTKE
   481  GIHLALVELL KNLTKYPTDR DSIWKCLKFL GSRHPTLVLP LVPELLSTHP FFDTAEPDMD
   541  DPAYIAVLVL IFNAAKTCPT MPALFSDHTF RHYAYLRDSL SHLVPALRLP GRKLVSSAVS
   601  PSIIPQEDPS QQFLQQSLER VYSLQHLDPQ GAQELLEFTI RDLQRLGELQ SELAGVADFS
   661  ATYLRCQLLL IKALQEKLWN VAAPLYLKQS DLASAAAKQI MEETYKMEFM YSGVENKQVV
   721  IIHHMRLQAK ALQLIVTART TRGLDPLFGM CEKFLQEVDF FQRYFIADLP HLQDSFVDKL
   781  LDLMPRLMTS KPAEVVKILQ TMLRQSAFLH LPLPEQIHKA SATIIEPAGE SDNPLRFTSG
   841  LVVALDVDAT LEHVQDPQNT VKVQVLYPDG QAQMIHPKPA DFRNPGPGRH RLITQVYLSH
   901  TAWTEACQVE VRLLLAYNSS ARIPKCPWME GGEMSPQVET SIEGTIPFSK PVKVYIMPKP
   961  ARR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 13 nTPM
  • tonsil: 13 nTPM
  • lymph node: 11 nTPM
  • bone marrow: 10 nTPM
  • appendix: 9.7 nTPM
  • rectum: 9.5 nTPM

Single-cell type

  • myonuclei: 146 nCPM
  • epicardial cells: 123 nCPM
  • cardiomyocytes: 96 nCPM
  • fibro-adipogenic progenitors: 92 nCPM
  • adipocytes: 90 nCPM
  • gonadotrophs: 73 nCPM

Immune cell

  • MAIT T-cell: 17 nTPM
  • T-reg: 17 nTPM
  • naive CD4 T-cell: 17 nTPM
  • NK-cell: 17 nTPM
  • intermediate monocyte: 16 nTPM
  • myeloid DC: 15 nTPM

Brain region

  • white matter: 18 nTPM
  • cerebellum: 14 nTPM
  • medulla oblongata: 14 nTPM
  • pons: 12 nTPM
  • choroid plexus: 12 nTPM
  • midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
1.25
DepMap mean gene effect
-1.58
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS4 as an antibody target. Whether an autoantibody or antibody against INTS4 could matter depends on whether native INTS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INTS4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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