Seroatlas · Human Serome Atlas

TEKT4

Tektin-4

Also known as: MGC27019, TEKT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WW24
Gene
TEKT4
Ensembl
ENSG00000163060
Chromosome
2
Canonical length
435 aa
Protein class
Predicted intracellular proteins
Subcellular location
Perinuclear theca,Connecting piece,Flagellar centriole,Principal piece,End piece,Annulus

OverviewNCBI Gene

Predicted to be involved in cilium assembly and flagellated sperm motility. Predicted to act upstream of with a positive effect on regulation of brood size. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>Q8WW24|TEKT4
     1  MAQTVPPCEL PCKEYDVARN TGAYTSSGLA TASFRTSKYL LEEWFQNCYA RYHQAFADRD
    61  QSERQRHESQ QLATETQALA QRTQQDSTRT VGERLQDTHS WKSELQREME ALAAETNLLL
   121  AQKQRLERAL DATEVPFSIT TDNLQCRERR EHPNLVRDHV ETELLKEAEL IRNIQELLKR
   181  TIMQAVSQIR LNREHKETCE MDWSDKMEAY NIDETCGRHH SQSTEVQAHP YSTTFQESAS
   241  TPETRAKFTQ DNLCRAQRER LASANLRVLV DCILRDTSED LRLQCDAVNL AFGRRCEELE
   301  DARYKLHHHL HKTLREITDQ EHNVAALKQA IKDKEAPLHV AQTRLYLRSH RPNMELCRDA
   361  AQFRLLSEVE ELNMSLTALR EKLLEAEQSL RNLEDIHMSL EKDIAAMTNS LFIDRQKCMA
   421  HRTRYPTILQ LAGYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEKT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • fallopian tube: 2.3 nTPM
  • hippocampal formation: 0.6 nTPM
  • hypothalamus: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • amygdala: 0.4 nTPM

Single-cell type

  • late spermatids: 172 nCPM
  • early spermatids: 132 nCPM
  • late primary spermatocytes: 99 nCPM
  • respiratory ciliated cells: 87 nCPM
  • fallopian tube ciliated cells: 72 nCPM
  • epididymal efferent duct ciliated cells: 57 nCPM

Immune cell

  • plasmacytoid DC: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • midbrain: 3.1 nTPM
  • medulla oblongata: 1.3 nTPM
  • pons: 0.7 nTPM
  • spinal cord: 0.6 nTPM
  • hypothalamus: 0.4 nTPM
  • white matter: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.56
gnomAD pLI
0
gnomAD missense Z
-1.71
DepMap mean gene effect
-0.3
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEKT4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEKT4 as an antibody target. Whether an autoantibody or antibody against TEKT4 could matter depends on whether native TEKT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEKT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEKT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEKT4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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