Seroatlas · Human Serome Atlas

TRIP6

Thyroid receptor-interacting protein 6

Also known as: MGC10556, MGC10558, MGC29959, MGC3837, MGC4423, OIP1, TRIP6_HUMAN, ZRP-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15654
Gene
TRIP6
Ensembl
ENSG00000087077
Chromosome
7
Canonical length
476 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Focal adhesion sites,Cytosol

OverviewNCBI Gene

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q15654|TRIP6
     1  MSGPTWLPPK QPEPARAPQG RAIPRGTPGP PPAHGAALQP HPRVNFCPLP SEQCYQAPGG
    61  PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL SSTLAELNGG RGHASRRPDR
   121  QAYEPPPPPA YRTGSLKPNP ASPLPASPYG GPTPASYTTA STPAGPAFPV QVKVAQPVRG
   181  CGPPRRGASQ ASGPLPGPHF PLPGRGEVWG PGYRSQREPG PGAKEEAAGV SGPAGRGRGG
   241  EHGPQVPLSQ PPEDELDRLT KKLVHDMNHP PSGEYFGQCG GCGEDVVGDG AGVVALDRVF
   301  HVGCFVCSTC RAQLRGQHFY AVERRAYCEG CYVATLEKCA TCSQPILDRI LRAMGKAYHP
   361  GCFTCVVCHR GLDGIPFTVD ATSQIHCIED FHRKFAPRCS VCGGAIMPEP GQEETVRIVA
   421  LDRSFHIGCY KCEECGLLLS SEGECQGCYP LDGHILCKAC SAWRIQELSA TVTTDC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • endometrium: 75 nTPM
  • blood vessel: 75 nTPM
  • cervix: 68 nTPM
  • esophagus: 68 nTPM
  • kidney: 68 nTPM
  • choroid plexus: 60 nTPM

Single-cell type

  • esophageal basal cells: 174 nCPM
  • migrating cytotrophoblasts: 172 nCPM
  • decidual stromal cells: 166 nCPM
  • syncytiotrophoblasts: 143 nCPM
  • esophageal suprabasal cells: 140 nCPM
  • basal keratinocytes: 131 nCPM

Immune cell

  • plasmacytoid DC: 5.2 nTPM
  • non-classical monocyte: 3.9 nTPM
  • memory B-cell: 2.5 nTPM
  • naive B-cell: 2.4 nTPM
  • intermediate monocyte: 2.1 nTPM
  • myeloid DC: 1.9 nTPM

Brain region

  • medulla oblongata: 44 nTPM
  • choroid plexus: 42 nTPM
  • basal ganglia: 40 nTPM
  • thalamus: 39 nTPM
  • midbrain: 35 nTPM
  • spinal cord: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIP6 as an antibody target. Whether an autoantibody or antibody against TRIP6 could matter depends on whether native TRIP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIP6 is annotated at the cell surface, where native TRIP6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRIP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIP6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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