Seroatlas · Human Serome Atlas

LAX1

Lymphocyte transmembrane adapter 1

Also known as: FLJ20340, LAX, LAX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWV1
Gene: LAX1
Ensembl: ENSG00000122188
Chromosome: 1
Canonical length: 398 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables SH2 domain binding activity and protein kinase binding activity. Involved in several processes, including B cell activation; negative regulation of MAPK cascade; and negative regulation of T cell activation. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>Q8IWV1|LAX1
     1  MDGVTPTLST IRGRTLESST LHVTPRSLDR NKDQITNIFS GFAGLLAILL VVAVFCILWN
    61  WNKRKKRQVP YLRVTVMPLL TLPQTRQRAK NIYDILPWRQ EDLGRHESRS MRIFSTESLL
   121  SRNSESPEHV PSQAGNAFQE HTAHIHATEY AVGIYDNAMV PQMCGNLTPS AHCINVRASR
   181  DCASISSEDS HDYVNVPTAE EIAETLASTK SPSRNLFVLP STQKLEFTEE RDEGCGDAGD
   241  CTSLYSPGAE DSDSLSNGEG SSQISNDYVN MTGLDLSAIQ ERQLWVAFQC CRDYENVPAA
   301  DPSGSQQQAE KDVPSSNIGH VEDKTDDPGT HVQCVKRTFL ASGDYADFQP FTQSEDSQMK
   361  HREEMSNEDS SDYENVLTAK LGGRDSEQGP GTQLLPDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

tonsil: 20 nTPM
lymph node: 11 nTPM
thymus: 10 nTPM
appendix: 8.3 nTPM
spleen: 6.8 nTPM
urinary bladder: 4.8 nTPM

Single-cell type

mast cells: 227 nCPM
plasma cells: 103 nCPM
t-cells: 61 nCPM
nk-cells: 51 nCPM
b-cells: 21 nCPM
paneth cells: 16 nCPM

Immune cell

gdT-cell: 12 nTPM
memory CD8 T-cell: 9.4 nTPM
MAIT T-cell: 9.1 nTPM
T-reg: 8.1 nTPM
memory B-cell: 7.5 nTPM
memory CD4 T-cell: 7.1 nTPM

Brain region

white matter: 2.6 nTPM
pons: 2.4 nTPM
medulla oblongata: 2.2 nTPM
cerebellum: 2.1 nTPM
cerebral cortex: 1.9 nTPM
choroid plexus: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Lymphocyte transmembrane adapter 1
Lymphocyte activation family X

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAX1 as an antibody target. Whether an autoantibody or antibody against LAX1 could matter depends on whether native LAX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAX1 is annotated at the cell surface, where native LAX1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LAX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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