Seroatlas · Human Serome Atlas

LAT

Linker for activation of T-cells family member 1

Also known as: LAT_HUMAN, LAT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43561
Gene
LAT
Ensembl
ENSG00000213658
Chromosome
16
Canonical length
262 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins
Subcellular location
Golgi apparatus,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>O43561|LAT
     1  MEEAILVPCV LGLLLLPILA MLMALCVHCH RLPGSYDSTS SDSLYPRGIQ FKRPHTVAPW
    61  PPAYPPVTSY PPLSQPDLLP IPRSPQPLGG SHRTPSSRRD SDGANSVASY ENEGASGIRG
   121  AQAGWGVWGP SWTRLTPVSL PPEPACEDAD EDEDDYHNPG YLVVLPDSTP ATSTAAPSAP
   181  ALSTPGIRDS AFSMESIDDY VNVPESGESA EASLDGSREY VNVSQELHPG AAKTEPAALS
   241  SQEAEEVEEE GAPDYENLQE LN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
106 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 106 nTPM
  • lymph node: 59 nTPM
  • blood vessel: 31 nTPM
  • spleen: 30 nTPM
  • colon: 30 nTPM
  • tonsil: 26 nTPM

Single-cell type

  • proximal tubule cells: 11 nCPM
  • platelets: 9.8 nCPM
  • astrocytes: 9 nCPM
  • t-cells: 8.4 nCPM
  • renal connecting tubule cells: 7.7 nCPM
  • brain inhibitory neurons: 7.2 nCPM

Immune cell

  • T-reg: 412 nTPM
  • basophil: 309 nTPM
  • memory CD8 T-cell: 307 nTPM
  • gdT-cell: 304 nTPM
  • memory CD4 T-cell: 295 nTPM
  • naive CD4 T-cell: 276 nTPM

Brain region

  • thalamus: 4.4 nTPM
  • hypothalamus: 4.1 nTPM
  • cerebral cortex: 4 nTPM
  • basal ganglia: 3.4 nTPM
  • cerebellum: 3.2 nTPM
  • hippocampal formation: 3.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LAT.

Disease | AllUniProt

Conditions LAT is implicated in, by any mechanism.

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 235 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Severe combined immunodeficiency due to LAT deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.01
gnomAD missense Z
0.63
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Linker-for-activation of T cells (LAT) protein
  • Linker for activation of T-cells

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAT as an antibody target. Whether an autoantibody or antibody against LAT could matter depends on whether native LAT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAT is annotated at the cell surface, where native LAT is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LAT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LAT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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