Seroatlas · Human Serome Atlas

TSC22D1

TSC22 domain family protein 1

Also known as: MGC17597, T22D1_HUMAN, TGFB1I4, TSC22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15714
Gene: TSC22D1
Ensembl: ENSG00000102804
Chromosome: 13
Canonical length: 1073 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

1073 residues, UniProt reviewed canonical sequence.

>Q15714|TSC22D1
     1  MHQPPESTAA AAAAADISAR KMAHPAMFPR RGSGSGSASA LNAAGTGVGS NATSSEDFPP
    61  PSLLQPPPPA ASSTSGPQPP PPQSLNLLSQ AQLQAQPLAP GGTQMKKKSG FQITSVTPAQ
   121  ISASISSNNS IAEDTESYDD LDESHTEDLS SSEILDVSLS RATDLGEPER SSSEETLNNF
   181  QEAETPGAVS PNQPHLPQPH LPHLPQQNVV INGNAHPHHL HHHHQIHHGH HLQHGHHHPS
   241  HVAVASASIT GGPPSSPVSR KLSTTGSSDS ITPVAPTSAV SSSGSPASVM TNMRAPSTTG
   301  GIGINSVTGT STVNNVNITA VGSFNPNVTS SMLGNVNIST SNIPSAAGVS VGPGVTSGVN
   361  VNILSGMGNG TISSSAAVSS VPNAAAGMTG GSVSSQQQQP TVNTSRFRVV KLDSSSEPFK
   421  KGRWTCTEFY EKENAVPATE GVLINKVVET VKQNPIEVTS ERESTSGSSV SSSVSTLSHY
   481  TESVGSGEMG APTVVVQQQQ QQQQQQQQQP ALQGVTLQQM DFGSTGPQSI PAVSIPQSIS
   541  QSQISQVQLQ SQELSYQQKQ GLQPVPLQAT MSAATGIQPS PVNVVGVTSA LGQQPSISSL
   601  AQPQLPYSQA APPVQTPLPG APPPQQLQYG QQQPMVSTQM APGHVKSVTQ NPASEYVQQQ
   661  PILQTAMSSG QPSSAGVGAG TTVIPVAQPQ GIQLPVQPTA VPAQPAGASV QPVGQAPAAV
   721  SAVPTGSQIA NIGQQANIPT AVQQPSTQVP PSVIQQGAPP SSQVVPPAQT GIIHQGVQTS
   781  APSLPQQLVI ASQSSLLTVP PQPQGVEPVA QGIVSQQLPA VSSLPSASSI SVTSQVSSTG
   841  PSGMPSAPTN LVPPQNIAQT PATQNGNLVQ SVSQPPLIAT NTNLPLAQQI PLSSTQFSAQ
   901  SLAQAIGSQI EDARRAAEPS LVGLPQTISG DSGGMSAVSD GSSSSLAASA SLFPLKVLPL
   961  TTPLVDGEDE SSSGASVVAI DNKIEQAMDL VKSHLMYAVR EEVEVLKEQI KELIEKNSQL
  1021  EQENNLLKTL ASPEQLAQFQ AQLQTGSPPA TTQPQGTTQP PAQPASQGSG PTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSC22D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 338 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 338 nTPM
cerebral cortex: 257 nTPM
basal ganglia: 232 nTPM
midbrain: 213 nTPM
amygdala: 203 nTPM
hypothalamus: 178 nTPM

Single-cell type

platelets: 3,506 nCPM
choroid plexus epithelial cells: 2,316 nCPM
late spermatids: 1,684 nCPM
myonuclei: 1,518 nCPM
syncytiotrophoblasts: 1,390 nCPM
thymic myoid cells: 1,190 nCPM

Immune cell

total PBMC: 50 nTPM
basophil: 45 nTPM
plasmacytoid DC: 18 nTPM
NK-cell: 17 nTPM
neutrophil: 8.6 nTPM
eosinophil: 5.8 nTPM

Brain region

choroid plexus: 282 nTPM
basal ganglia: 265 nTPM
midbrain: 258 nTPM
hippocampal formation: 257 nTPM
cerebral cortex: 256 nTPM
thalamus: 256 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.96
gnomAD missense Z: -0.88
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSC22D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSC22D1 as an antibody target. Whether an autoantibody or antibody against TSC22D1 could matter depends on whether native TSC22D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSC22D1 is annotated at the cell surface, where native TSC22D1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSC22D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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