Seroatlas · Human Serome Atlas

GPRIN1

G protein-regulated inducer of neurite outgrowth 1

Also known as: GRIN1, GRIN1_HUMAN, KIAA1893

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z2K8
Gene: GPRIN1
Ensembl: ENSG00000169258
Chromosome: 5
Canonical length: 1008 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable phosphoprotein binding activity. Predicted to be involved in neuron projection development. Predicted to be located in growth cone. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1008 residues, UniProt reviewed canonical sequence.

>Q7Z2K8|GPRIN1
     1  MDTAEDPAWL QLLQKDSSPP GPRPTAFFCP QDGSLGAGSS AMRDYCPSQQ KASPAPPRHT
    61  PDQSPGMESR HRSPSGAGEG ASCSDGPRGS LACPSPTCFS PQESPSKETL EAHGASISGT
   121  PEATTSGKPE PVSSVKTEPK SSDDRNPMFL EKMDFKSSKQ ADSTSIGKED PGSSRKADPM
   181  FTGKAEPEIL GKGDPVAPGR MDPMTVRKED LGSLGKVDPL CSSKTYTVSP RKEDPGSLRK
   241  VDPVSSDKVD PVFPRKEEPR YSGKEHPVSS EKVAPTSAEK VDLVLSGKRD PGPSGKADPM
   301  PLESMDSAST GKTEPGLLGK LIPGSSGKNG PVSSGTGAPG SLGRLDPTCL GMADPASVGN
   361  VETVPATKED SRFLGKMDPA SSGEGRPVSG HTDTTASAKT DLTSLKNVDP MSSGKVDPVS
   421  LGKMDPMCSG KPELLSPGQA ERVSVGKAGT VSPGKEDPVS SRREDPISAG SRKTSSEKVN
   481  PESSGKTNPV SSGPGDPRSL GTAGPPSAVK AEPATGGKGD PLSSEKAGLV ASGKAAPTAS
   541  GKAEPLAVGK EDPVSKGKAD AGPSGQGDSV SIGKVVSTPG KTVPVPSGKV DPVSLGKAEA
   601  IPEGKVGSLP LEKGSPVTTT KADPRASGKA QPQSGGKAET KLPGQEGAAA PGEAGAVCLK
   661  KETPQASEKV DPGSCRKAEP LASGKGEPVS LGKADSAPSR KTESPSLGKV VPLSLEKTKP
   721  SSSSRQLDRK ALGSARSPEG ARGSEGRVEP KAEPVSSTEA SSLGQKDLEA AGAERSPCPE
   781  AAAPPPGPRT RDNFTKAPSW EASAPPPPRE DAGTQAGAQA CVSVAVSPMS PQDGAGGSAF
   841  SFQAAPRAPS PPSRRDAGLQ VSLGAAETRS VATGPMTPQA AAPPAFPEVR VRPGSALAAA
   901  VAPPEPAEPV RDVSWDEKGM TWEVYGAAME VEVLGMAIQK HLERQIEEHG RQGAPAPPPA
   961  ARAGPGRSGS VRTAPPDGAA KRPPGLFRAL LQSVRRPRCC SRAGPTAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPRIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 21 nTPM
cerebral cortex: 20 nTPM
amygdala: 17 nTPM
hippocampal formation: 15 nTPM
hypothalamus: 13 nTPM
pituitary gland: 7.6 nTPM

Single-cell type

retinal amacrine cells: 23 nCPM
retinal bipolar cells: 21 nCPM
retinal horizontal cells: 14 nCPM
other brain neurons: 13 nCPM
brain excitatory neurons: 12 nCPM
corticotrophs: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 60 nTPM
cerebral cortex: 55 nTPM
amygdala: 49 nTPM
hypothalamus: 47 nTPM
basal ganglia: 47 nTPM
cerebellum: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 0.34
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

neuron projection development

Molecular functions

phosphoprotein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPRIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPRIN1 as an antibody target. Whether an autoantibody or antibody against GPRIN1 could matter depends on whether native GPRIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPRIN1 is annotated at the cell surface, where native GPRIN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPRIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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