Seroatlas · Human Serome Atlas

RGS8

Regulator of G-protein signaling 8

Also known as: MGC119067, MGC119068, MGC119069, RGS8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57771
Gene: RGS8
Ensembl: ENSG00000135824
Chromosome: 1
Canonical length: 180 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>P57771|RGS8
     1  MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA TRWADSFDVL
    61  LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK LVSKAHRIFE EFVDVQAPRE
   121  VNIDFQTREA TRKNLQEPSL TCFDQAQGKV HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

retina: 28 nTPM
basal ganglia: 27 nTPM
cerebellum: 8.7 nTPM
midbrain: 7.7 nTPM
thyroid gland: 6.2 nTPM
hypothalamus: 5.8 nTPM

Single-cell type

retinal bipolar cells: 178 nCPM
retinal amacrine cells: 107 nCPM
brain inhibitory neurons: 44 nCPM
lactotrophs: 37 nCPM
thyrotrophs: 35 nCPM
late spermatids: 35 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 170 nTPM
basal ganglia: 87 nTPM
midbrain: 66 nTPM
pons: 59 nTPM
hypothalamus: 50 nTPM
amygdala: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.3
gnomAD missense Z: 1.28
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RGS domain
RGS, subdomain 1/3
RGS domain superfamily
RGS, subdomain 2
Regulator of G protein signaling domain
Regulator of G-protein signalling 8, RGS domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS8 as an antibody target. Whether an autoantibody or antibody against RGS8 could matter depends on whether native RGS8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS8 is annotated at the cell surface, where native RGS8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RGS8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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