XAGE3
X antigen family member 3
Also known as: CT12.3a, CT12.3b, GAGED4, PLAC6, pp9012, XAGE-3, XAGE3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WTP9
- Gene
- XAGE3
- Ensembl
- ENSG00000171402
- Chromosome
- X
- Canonical length
- 111 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Plasma membrane
OverviewNCBI Gene
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
111 residues, UniProt reviewed canonical sequence.
>Q8WTP9|XAGE3
1 MIWRGRSTYR PRPRRSVPPP ELIGPMLEPG DEEPQQEEPP TESRDPAPGQ EREEDQGAAE
61 TQVPDLEADL QELSQSKTGG ECGNGPDDQG KILPKSEQFK MPEGGDRQPQ VLocalizationUniProt · AlphaFold · HPA
Whether an antibody against XAGE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 358 nTPM
Expression across tissuesHPA
Tissue
- placenta: 358 nTPM
- adipose tissue: 2.9 nTPM
- liver: 1.9 nTPM
- testis: 1.4 nTPM
- epididymis: 0.5 nTPM
- breast: 0.4 nTPM
Single-cell type
- migrating cytotrophoblasts: 3,157 nCPM
- syncytiotrophoblasts: 3,075 nCPM
- cytotrophoblasts: 2,353 nCPM
- extravillous trophoblasts: 1,500 nCPM
- hofbauer cells: 33 nCPM
- early primary spermatocytes: 16 nCPM
Immune cell
- memory B-cell: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- white matter: 0.3 nTPM
- cerebral cortex: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.31
- gnomAD pLI
- 0.09
- gnomAD missense Z
- -0.58
- DepMap mean gene effect
- -0.25
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
InteractionsUniProt · HPA
Protein binding partners of XAGE3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads XAGE3 as an antibody target. Whether an autoantibody or antibody against XAGE3 could matter depends on whether native XAGE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
XAGE3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label XAGE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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