XAGE2
X antigen family member 2
Also known as: CT12.2, GAGED3, XAGE-2, XAGE2_HUMAN, XAGE2B
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96GT9
- Gene
- XAGE2
- Ensembl
- ENSG00000155622
- Chromosome
- X
- Canonical length
- 111 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Plasma membrane
OverviewNCBI Gene
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis, and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
111 residues, UniProt reviewed canonical sequence.
>Q96GT9|XAGE2
1 MSWRGRSTYR PRPRRSLQPP ELIGAMLEPT DEEPKEEKPP TKSRNPTPDQ KREDDQGAAE
61 IQVPDLEADL QELCQTKTGD GCEGGTDVKG KILPKAEHFK MPEAGEGKSQ VLocalizationUniProt · AlphaFold · HPA
Whether an antibody against XAGE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.7
- Highest tissue expression
- 187 nTPM
Expression across tissuesHPA
Tissue
- placenta: 187 nTPM
- lung: 5.3 nTPM
- pancreas: 0.4 nTPM
- testis: 0.4 nTPM
- kidney: 0.3 nTPM
- skin: 0.3 nTPM
Single-cell type
- extravillous trophoblasts: 2,665 nCPM
- migrating cytotrophoblasts: 1,890 nCPM
- syncytiotrophoblasts: 1,649 nCPM
- cytotrophoblasts: 1,044 nCPM
- transitional alveolar cells: 40 nCPM
- alveolar cells type 2: 22 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 0.2 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Protein domainsUniProt · Pfam · InterPro
InteractionsUniProt · HPA
Protein binding partners of XAGE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads XAGE2 as an antibody target. Whether an autoantibody or antibody against XAGE2 could matter depends on whether native XAGE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
XAGE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label XAGE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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