Seroatlas · Human Serome Atlas

FAM167A

Protein FAM167A

Also known as: C8orf13, DIORA-1, F167A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KS9
Gene: FAM167A
Ensembl: ENSG00000154319
Chromosome: 8
Canonical length: 214 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

No narrative summary is available for FAM167A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q96KS9|FAM167A
     1  MSVPQIHVEE VGAEEGAGAA APPDDHLRSL KALTEKLRLE TRRPSYLEWQ ARLEEHTWPF
    61  PRPAAEPQAS LEEGERGGQE PLLPLREAGQ HPPSARSASQ GARPLSTGKL EGFQSIDEAI
   121  AWLRKELTEM RLQDQQLARQ LMRLRGDINK LKIEHTCRLH RRMLNDATYE LEERDELADL
   181  FCDSPLASSF SLSTPLKLIG VTKMNINSRR FSLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM167A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 50 nTPM
cerebral cortex: 24 nTPM
amygdala: 20 nTPM
basal ganglia: 17 nTPM
pituitary gland: 17 nTPM
hippocampal formation: 14 nTPM

Single-cell type

bergmann glia: 43 nCPM
astrocytes: 32 nCPM
choroid plexus epithelial cells: 18 nCPM
ependymal cells: 9.1 nCPM
loop of henle epithelial cells: 8.6 nCPM
late spermatids: 8.3 nCPM

Immune cell

memory B-cell: 1.2 nTPM
intermediate monocyte: 0.5 nTPM
non-classical monocyte: 0.5 nTPM
naive B-cell: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM
NK-cell: 0.3 nTPM

Brain region

thalamus: 43 nTPM
medulla oblongata: 39 nTPM
midbrain: 35 nTPM
hypothalamus: 33 nTPM
spinal cord: 33 nTPM
hippocampal formation: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.97
gnomAD pLI: 0
gnomAD missense Z: -1.72
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of FAM167A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM167A as an antibody target. Whether an autoantibody or antibody against FAM167A could matter depends on whether native FAM167A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM167A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM167A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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