Seroatlas · Human Serome Atlas

FIBP

Acidic fibroblast growth factor intracellular-binding protein

Also known as: FGFIBP, FIBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43427
Gene: FIBP
Ensembl: ENSG00000172500
Chromosome: 11
Canonical length: 364 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>O43427|FIBP
     1  MTSELDIFVG NTTLIDEDVY RLWLDGYSVT DAVALRVRSG ILEQTGATAA VLQSDTMDHY
    61  RTFHMLERLL HAPPKLLHQL IFQIPPSRQA LLIERYYAFD EAFVREVLGK KLSKGTKKDL
   121  DDISTKTGIT LKSCRRQFDN FKRVFKVVEE MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA
   181  NNRFETGKKK LQYLSFGDFA FCAELMIQNW TLGAVGEAPT DPDSQMDDMD MDLDKEFLQD
   241  LKELKVLVAD KDLLDLHKSL VCTALRGKLG VFSEMEANFK NLSRGLVNVA AKLTHNKDVR
   301  DLFVDLVEKF VEPCRSDHWP LSDVRFFLNQ YSASVHSLDG FRHQALWDRY MGTLRGCLLR
   361  LYHD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FIBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 64 nTPM
testis: 55 nTPM
amygdala: 53 nTPM
tongue: 53 nTPM
heart muscle: 49 nTPM
choroid plexus: 47 nTPM

Single-cell type

late spermatids: 1,044 nCPM
late primary spermatocytes: 226 nCPM
decidual stromal cells: 184 nCPM
early spermatids: 173 nCPM
enterocytes: 172 nCPM
extravillous trophoblasts: 167 nCPM

Immune cell

myeloid DC: 165 nTPM
non-classical monocyte: 151 nTPM
intermediate monocyte: 137 nTPM
basophil: 124 nTPM
classical monocyte: 121 nTPM
total PBMC: 109 nTPM

Brain region

pons: 56 nTPM
medulla oblongata: 54 nTPM
cerebral cortex: 51 nTPM
hypothalamus: 49 nTPM
thalamus: 47 nTPM
midbrain: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FIBP.

Disease | AllUniProt

Conditions FIBP is implicated in, by any mechanism.

Thauvin-Robinet-Faivre syndrome (TROFAS) MIM:617107

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 103 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Tall stature-intellectual disability-renal anomalies syndrome
6 conditions
FIBP-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 1.03
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

fibroblast growth factor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Acidic fibroblast growth factor intracellular-binding protein
Acidic fibroblast growth factor binding (FIBP)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FIBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FIBP as an antibody target. Whether an autoantibody or antibody against FIBP could matter depends on whether native FIBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FIBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FIBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...