FGFBP1

Protein identityUniProt · HPA

UniProt accession

Q14512

Gene

FGFBP1

Ensembl

ENSG00000137440

Chromosome

4

Canonical length

234 aa

Protein class

Cancer-related genes, Predicted secreted proteins

Secretome location

Secreted in other tissues

OverviewNCBI Gene

This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q14512|FGFBP1
     1  MKICSLTLLS FLLLAAQVLL VEGKKKVKNG LHSKVVSEQK DTLGNTQIKQ KSRPGNKGKF
    61  VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP TSCLKLKDER VYWKQVARNL
   121  RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSP REHIKGKETT
   181  PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGFBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

413 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.06

gnomAD pLI

0.59

gnomAD missense Z

-0.85

DepMap mean gene effect

0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell signaling
• fibroblast growth factor receptor signaling pathway
• myoblast proliferation
• negative regulation of cell population proliferation
• positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
• positive regulation of cell migration involved in sprouting angiogenesis
• positive regulation of fibroblast growth factor receptor signaling pathway
• positive regulation of myoblast proliferation
• signal transduction

Molecular functions

• fibroblast growth factor binding
• growth factor binding
• heparin binding

Cellular components

• cell surface
• extracellular region
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• FGF binding 1
• FGF binding protein 1 (FGF-BP1)

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Growth factor binding
• Membrane
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of FGFBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FGF1
• FGF10
• FGF2
• FGF22
• FGF7
• HSPG2