S100A13

Protein identityUniProt · HPA

UniProt accession

Q99584

Gene

S100A13

Ensembl

ENSG00000189171

Chromosome

1

Canonical length

98 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Nucleoli,Plasma membrane,Cytosol

Secretome location

Secreted in other tissues

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

98 residues, UniProt reviewed canonical sequence.

>Q99584|S100A13
     1  MAAEPLTELE ESIETVVTTF FTFARQEGRK DSLSVNEFKE LVTQQLPHLL KDVGSLDEKM
    61  KSLDVNQDSE LKFNEYWRLI GELAKEIRKK KDLKIRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100A13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

415 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.67

gnomAD pLI

0.05

gnomAD missense Z

0.32

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mast cell degranulation
• positive regulation of canonical NF-kappaB signal transduction
• positive regulation of cytokine production
• positive regulation of interleukin-1 alpha production
• protein transport

Molecular functions

• calcium ion binding
• calcium-dependent protein binding
• copper ion binding
• fibroblast growth factor binding
• lipid binding
• protein homodimerization activity
• RAGE receptor binding
• zinc ion binding

Cellular components

• cytoplasm
• cytosol
• extracellular region
• extracellular space
• nucleolus
• nucleoplasm
• nucleus
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• EF-hand domain pair
• S100/CaBP-9k-type, calcium binding, subdomain
• S-100/ICaBP type calcium binding domain

KeywordsUniProt

• Calcium
• Copper
• Cytoplasm
• Lipid-binding
• Metal-binding
• Phosphoprotein
• Protein transport
• Repeat
• Secreted
• Transport

InteractionsUniProt · HPA

Protein binding partners of S100A13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FGF1
• IL1A
• SYT1