Seroatlas · Human Serome Atlas

SATB1

DNA-binding protein SATB1

Also known as: SATB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q01826
Gene: SATB1
Ensembl: ENSG00000182568
Chromosome: 3
Canonical length: 763 aa
Protein class: Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

763 residues, UniProt reviewed canonical sequence.

>Q01826|SATB1
     1  MDHLNEATQG KEHSEMSNNV SDPKGPPAKI ARLEQNGSPL GRGRLGSTGA KMQGVPLKHS
    61  GHLMKTNLRK GTMLPVFCVV EHYENAIEYD CKEEHAEFVL VRKDMLFNQL IEMALLSLGY
   121  SHSSAAQAKG LIQVGKWNPV PLSYVTDAPD ATVADMLQDV YHVVTLKIQL HSCPKLEDLP
   181  PEQWSHTTVR NALKDLLKDM NQSSLAKECP LSQSMISSIV NSTYYANVSA AKCQEFGRWY
   241  KHFKKTKDMM VEMDSLSELS QQGANHVNFG QQPVPGNTAE QPPSPAQLSH GSQPSVRTPL
   301  PNLHPGLVST PISPQLVNQQ LVMAQLLNQQ YAVNRLLAQQ SLNQQYLNHP PPVSRSMNKP
   361  LEQQVSTNTE VSSEIYQWVR DELKRAGISQ AVFARVAFNR TQGLLSEILR KEEDPKTASQ
   421  SLLVNLRAMQ NFLQLPEAER DRIYQDERER SLNAASAMGP APLISTPPSR PPQVKTATIA
   481  TERNGKPENN TMNINASIYD EIQQEMKRAK VSQALFAKVA ATKSQGWLCE LLRWKEDPSP
   541  ENRTLWENLS MIRRFLSLPQ PERDAIYEQE SNAVHHHGDR PPHIIHVPAE QIQQQQQQQQ
   601  QQQQQQQAPP PPQPQQQPQT GPRLPPRQPT VASPAESDEE NRQKTRPRTK ISVEALGILQ
   661  SFIQDVGLYP DEEAIQTLSA QLDLPKYTII KFFQNQRYYL KHHGKLKDNS GLEVDVAEYK
   721  EEELLKDLEE SVQDKNTNTL FSVKLEEELS VEGNTDINTD LKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SATB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 346 nTPM

Expression across tissuesHPA

Tissue

thymus: 346 nTPM
skeletal muscle: 90 nTPM
tongue: 51 nTPM
salivary gland: 44 nTPM
bone marrow: 38 nTPM
lymph node: 37 nTPM

Single-cell type

innate lymphoid cells: 398 nCPM
thymocytes: 393 nCPM
t-cells: 228 nCPM
nk-cells: 222 nCPM
lactotrophs: 183 nCPM
oligodendrocyte progenitor cells: 181 nCPM

Immune cell

naive CD4 T-cell: 105 nTPM
MAIT T-cell: 74 nTPM
naive CD8 T-cell: 65 nTPM
NK-cell: 61 nTPM
gdT-cell: 43 nTPM
memory CD4 T-cell: 29 nTPM

Brain region

cerebral cortex: 117 nTPM
basal ganglia: 84 nTPM
white matter: 71 nTPM
midbrain: 63 nTPM
hippocampal formation: 57 nTPM
choroid plexus: 54 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SATB1.

Disease | AllUniProt

Conditions SATB1 is implicated in, by any mechanism.

Den Hoed-de Boer-Voisin syndrome (DHDBV) MIM:619229
Developmental delay with dysmorphic facies and dental anomalies (DEFDA) MIM:619228

Disease | GeneticClinVar

36 pathogenic / likely-pathogenic of 233 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental delay with dysmorphic facies and dental anomalies
Kohlschutter-Tonz syndrome-like
Inborn genetic diseases
Neurodevelopmental delay
Neurodevelopmental disorder

Disease | ImmuneIEDB

Conditions an epitope on SATB1 was assayed in.

ovarian cancer T cell
prostate cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 3.98
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SATB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SATB1 as an antibody target. Whether an autoantibody or antibody against SATB1 could matter depends on whether native SATB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SATB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SATB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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