Dedicator of cytokinesis, C-terminal, lobe A
IPR043161
Definition
DOCK (dedicator of cytokinesis) proteins are potential guanine nucleotide exchange factors that activate some small GTPases, such as Rac, by exchanging bound GDP for free GTP PMID:12432077. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis PMID:12829596. Nucleotide exchange is catalysed by a conserved catalytic DHR2 domain situated within the C-terminal region which consists of three lobes. This entry represents lobe A of DHR2 which adopts a tetratricopeptide repeat-like fold of six antiparallel α-helices [[cite:PMID:21613211], [cite:PMID:32651375]].
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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