Dedicator of cytokinesis C/D, N terminal

Definition

This entry represents the N-terminal domain of the DOCK-C subfamily (DOCK 6, 7, 8) and DOCK-D subfamily (DOCK 9, 10, 11). DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [[cite:PMID:12432077],[cite:PMID:25022758]], required during several cellular processes, such as cell motility and phagocytosis. DOCK proteins are categorised into four subfamilies based on their sequence homology: DOCK-A (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) PMID:12432077.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• DOCK10
• DOCK11
• DOCK6
• DOCK7
• DOCK8
• DOCK9