Dedicator of cytokinesis, C-terminal, lobe C
IPR043162
Definition
DOCK (dedicator of cytokinesis) proteins are potential guanine nucleotide exchange factors that activate some small GTPases, such as Rac, by exchanging bound GDP for free GTP PMID:12432077. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis PMID:12829596. Nucleotide exchange is catalysed by a conserved catalytic DHR2 domain situated within the C-terminal region which consists of three lobes. This entry represents lobe C of DHR2 which folds to form an antiparallel α-helical bundle PMID:21613211.
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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