Seroatlas · Human Serome Atlas

NEURL1

E3 ubiquitin-protein ligase NEURL1

Also known as: h-neu, neu-1, NEUL1_HUMAN, NEURL, RNF67

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O76050
Gene
NEURL1
Ensembl
ENSG00000107954
Chromosome
10
Canonical length
574 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in negative regulation of Notch signaling pathway; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

574 residues, UniProt reviewed canonical sequence.

>O76050|NEURL1
     1  MGNNFSSIPS LPRGNPSRAP RGHPQNLKDS IGGPFPVTSH RCHHKQKHCP AVLPSGGLPA
    61  TPLLFHPHTK GSQILMDLSH KAVKRQASFC NAITFSNRPV LIYEQVRLKI TKKQCCWSGA
   121  LRLGFTSKDP SRIHPDSLPK YACPDLVSQS GFWAKALPEE FANEGNIIAF WVDKKGRVFH
   181  RINDSAVMLF FSGVRTADPL WALVDVYGLT RGVQLLDSEL VLPDCLRPRS FTALRRPSLR
   241  READDARLSV SLCDLNVPGA DGDEAAPAAG CPIPQNSLNS QHSRALPAQL DGDLRFHALR
   301  AGAHVRILDE QTVARVEHGR DERALVFTSR PVRVAETIFV KVTRSGGARP GALSFGVTTC
   361  DPGTLRPADL PFSPEALVDR KEFWAVCRVP GPLHSGDILG LVVNADGELH LSHNGAAAGM
   421  QLCVDASQPL WMLFGLHGTI TQIRILGSTI LAERGIPSLP CSPASTPTSP SALGSRLSDP
   481  LLSTCSSGPL GSSAGGTAPN SPVSLPESPV TPGLGQWSDE CTICYEHAVD TVIYTCGHMC
   541  LCYACGLRLK KALHACCPIC RRPIKDIIKT YRSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEURL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
136 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 136 nTPM
  • cerebellum: 63 nTPM
  • cerebral cortex: 58 nTPM
  • tongue: 56 nTPM
  • basal ganglia: 44 nTPM
  • amygdala: 41 nTPM

Single-cell type

  • late spermatids: 789 nCPM
  • rod photoreceptor cells: 380 nCPM
  • cone photoreceptor cells: 296 nCPM
  • syncytiotrophoblasts: 241 nCPM
  • salivary ionocytes: 212 nCPM
  • early spermatids: 210 nCPM

Immune cell

  • non-classical monocyte: 112 nTPM
  • intermediate monocyte: 45 nTPM
  • myeloid DC: 5.8 nTPM
  • plasmacytoid DC: 4.5 nTPM
  • total PBMC: 4 nTPM
  • classical monocyte: 2.8 nTPM

Brain region

  • cerebral cortex: 143 nTPM
  • hippocampal formation: 133 nTPM
  • basal ganglia: 120 nTPM
  • amygdala: 120 nTPM
  • cerebellum: 109 nTPM
  • white matter: 100 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0.01
gnomAD missense Z
2.54
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEURL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEURL1 as an antibody target. Whether an autoantibody or antibody against NEURL1 could matter depends on whether native NEURL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEURL1 is annotated at the cell surface, where native NEURL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NEURL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NEURL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...