Seroatlas · Human Serome Atlas

SYNJ2BP

Synaptojanin-2-binding protein

Also known as: Arip2, SYJ2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57105
Gene: SYNJ2BP
Ensembl: ENSG00000213463
Chromosome: 14
Canonical length: 145 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable type II activin receptor binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of sprouting angiogenesis; and regulation of signal transduction. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>P57105|SYNJ2BP
     1  MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN GAAALDGRLQ
    61  EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL QVQNGPIGHR GEGDPSGIPI
   121  FMVLVPVFAL TMVAAWAFMR YRQQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYNJ2BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

tongue: 27 nTPM
skeletal muscle: 27 nTPM
parathyroid gland: 23 nTPM
kidney: 20 nTPM
liver: 19 nTPM
duodenum: 18 nTPM

Single-cell type

parietal cells: 3.5 nCPM
gastric chief cells: 2.2 nCPM
epididymal clear cells: 2 nCPM
late primary spermatocytes: 1.8 nCPM
brain excitatory neurons: 1.6 nCPM
microglia: 1.5 nCPM

Immune cell

naive CD4 T-cell: 3.8 nTPM
naive CD8 T-cell: 3.1 nTPM
intermediate monocyte: 3 nTPM
myeloid DC: 3 nTPM
classical monocyte: 2.9 nTPM
memory CD4 T-cell: 2.7 nTPM

Brain region

choroid plexus: 28 nTPM
spinal cord: 22 nTPM
thalamus: 22 nTPM
amygdala: 21 nTPM
medulla oblongata: 21 nTPM
basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.51
gnomAD missense Z: 0.75
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYNJ2BP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYNJ2BP as an antibody target. Whether an autoantibody or antibody against SYNJ2BP could matter depends on whether native SYNJ2BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYNJ2BP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYNJ2BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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