Seroatlas · Human Serome Atlas

STAU2

Double-stranded RNA-binding protein Staufen homolog 2

Also known as: 39K2, STAU2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NUL3
Gene
STAU2
Ensembl
ENSG00000040341
Chromosome
8
Canonical length
570 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q9NUL3|STAU2
     1  MANPKEKTAM CLVNELARFN RVQPQYKLLN ERGPAHSKMF SVQLSLGEQT WESEGSSIKK
    61  AQQAVANKAL TESTLPKPVQ KPPKSNVNNN PGSITPTVEL NGLAMKRGEP AIYRPLDPKP
   121  FPNYRANYNF RGMYNQRYHC PVPKIFYVQL TVGNNEFFGE GKTRQAARHN AAMKALQALQ
   181  NEPIPERSPQ NGESGKDVDD DKDANKSEIS LVFEIALKRN MPVSFEVIKE SGPPHMKSFV
   241  TRVSVGEFSA EGEGNSKKLS KKRAATTVLQ ELKKLPPLPV VEKPKLFFKK RPKTIVKAGP
   301  EYGQGMNPIS RLAQIQQAKK EKEPDYVLLS ERGMPRRREF VMQVKVGNEV ATGTGPNKKI
   361  AKKNAAEAML LQLGYKASTN LQDQLEKTGE NKGWSGPKPG FPEPTNNTPK GILHLSPDVY
   421  QEMEASRHKV ISGTTLGYLS PKDMNQPSSS FFSISPTSNS SATIARELLM NGTSSTAEAI
   481  GLKGSSPTPP CSPVQPSKQL EYLARIQGFQ AALSALKQFS EQGLDPIDGA MNIEKGSLEK
   541  QAKHLREKAD NNQAPPGSIA QDCKKSNSAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAU2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 104 nTPM
  • tongue: 103 nTPM
  • heart muscle: 66 nTPM
  • cerebral cortex: 54 nTPM
  • esophagus: 33 nTPM
  • thymus: 33 nTPM

Single-cell type

  • choroid plexus epithelial cells: 374 nCPM
  • brain excitatory neurons: 344 nCPM
  • myonuclei: 319 nCPM
  • brain inhibitory neurons: 312 nCPM
  • other brain neurons: 287 nCPM
  • neutrophil progenitors: 285 nCPM

Immune cell

  • NK-cell: 45 nTPM
  • eosinophil: 43 nTPM
  • neutrophil: 31 nTPM
  • gdT-cell: 29 nTPM
  • T-reg: 26 nTPM
  • plasmacytoid DC: 25 nTPM

Brain region

  • cerebral cortex: 129 nTPM
  • cerebellum: 122 nTPM
  • white matter: 120 nTPM
  • basal ganglia: 108 nTPM
  • midbrain: 106 nTPM
  • medulla oblongata: 103 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
1.42
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAU2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAU2 as an antibody target. Whether an autoantibody or antibody against STAU2 could matter depends on whether native STAU2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAU2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAU2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STAU2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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