CYSRT1
Cysteine-rich tail protein 1
Also known as: C9orf169, CRTP1_HUMAN, MGC59937
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A8MQ03
- Gene
- CYSRT1
- Ensembl
- ENSG00000197191
- Chromosome
- 9
- Canonical length
- 144 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear speckles,Vesicles,Midbody
OverviewNCBI Gene
Enables identical protein binding activity. Involved in biological process involved in interaction with symbiont and establishment of skin barrier. Located in cornified envelope. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
144 residues, UniProt reviewed canonical sequence.
>A8MQ03|CYSRT1
1 MDPQEMVVKN PYAHISIPRA HLRPDLGQQL EVASTCSSSS EMQPLPVGPC APEPTHLLQP
61 TEVPGPKGAK GNQGAAPIQN QQAWQQPGNP YSSSQRQAGL TYAGPPPAGR GDDIAHHCCC
121 CPCCHCCHCP PFCRCHSCCC CVISLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CYSRT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.68
- Highest tissue expression
- 460 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 460 nTPM
- vagina: 106 nTPM
- cervix: 96 nTPM
- skin: 63 nTPM
- salivary gland: 50 nTPM
- tonsil: 14 nTPM
Single-cell type
- esophageal apical cells: 18,748 nCPM
- esophageal suprabasal cells: 1,382 nCPM
- suprabasal keratinocytes: 281 nCPM
- esophageal basal cells: 89 nCPM
- submucosal glandular cells: 26 nCPM
- ocular epithelial cells: 18 nCPM
Immune cell
- non-classical monocyte: 1 nTPM
- intermediate monocyte: 0.5 nTPM
- memory B-cell: 0.1 nTPM
- myeloid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
Brain region
- cerebral cortex: 6.6 nTPM
- medulla oblongata: 6 nTPM
- midbrain: 5.6 nTPM
- spinal cord: 4.7 nTPM
- hippocampal formation: 4.6 nTPM
- thalamus: 4.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.8
- gnomAD pLI
- 0.01
- DepMap mean gene effect
- -0.14
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Uncharacterised protein family UPF0574
- Protein of unknown function (DUF2477)
InteractionsUniProt · HPA
Protein binding partners of CYSRT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CYSRT1 as an antibody target. Whether an autoantibody or antibody against CYSRT1 could matter depends on whether native CYSRT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CYSRT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CYSRT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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