LCE4A
Late cornified envelope protein 4A
Also known as: LCE4A_HUMAN, LEP8, SPRL4A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5TA78
- Gene
- LCE4A
- Ensembl
- ENSG00000187170
- Chromosome
- 1
- Canonical length
- 99 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>Q5TA78|LCE4A
1 MSCQQNQQQC QPPPKCPIPK YPPKCPSKCA SSCPPPISSC CGSSSGGCGC CSSEGGGCCL
61 SHHRHHRSHC HRPKSSNCYG SGSGQQSGGS GCCSGGGCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LCE4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.74
- Highest tissue expression
- 4.2 nTPM
Expression across tissuesHPA
Tissue
- skin: 4.2 nTPM
- breast: 0.5 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- melanocytes: 0.2 nCPM
- undifferentiated spermatogonia: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.21
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LCE4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LCE4A as an antibody target. Whether an autoantibody or antibody against LCE4A could matter depends on whether native LCE4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LCE4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LCE4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...