Seroatlas · Human Serome Atlas

LCE1D

Late cornified envelope protein 1D

Also known as: LCE1D_HUMAN, LEP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T752
Gene: LCE1D
Ensembl: ENSG00000172155
Chromosome: 1
Canonical length: 114 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity. Involved in cognition. Acts upstream of or within cellular response to calcium ion. Located in cornified envelope and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>Q5T752|LCE1D
     1  MSCQQSQQQC QPPPKCTPKC TPKCPAPKCP PKCPPVSSCC SVSSGGCCGS SSGGGCGSNS
    61  GGCCSSGGGG CCLSHHRRHR SHRRRPQSSD CCSQPSGGSS CCGGGSSQHS GGCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCE1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.73
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

skin: 88 nTPM
skeletal muscle: 0.8 nTPM
cervix: 0.4 nTPM
bone marrow: 0.1 nTPM
salivary gland: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Keratinization

InteractionsUniProt · HPA

Protein binding partners of LCE1D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CYSRT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCE1D as an antibody target. Whether an autoantibody or antibody against LCE1D could matter depends on whether native LCE1D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCE1D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LCE1D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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