Seroatlas · Human Serome Atlas

LCE3D

Late cornified envelope protein 3D

Also known as: LCE3D_HUMAN, LEP16, SPRL6A, SPRL6B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYE3
Gene: LCE3D
Ensembl: ENSG00000163202
Chromosome: 1
Canonical length: 92 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in keratinization. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>Q9BYE3|LCE3D
     1  MSCQQNQQQC QPPPKCPSPK CPPKSPVQCL PPASSGCAPS SGGCGPSSEG GCFLNHHRRH
    61  HRCRRQRPNS CDRGSGQQGG GSGCGHGSGG CC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCE3D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.74
Highest tissue expression: 238 nTPM

Expression across tissuesHPA

Tissue

cervix: 238 nTPM
vagina: 199 nTPM
skin: 80 nTPM
tonsil: 79 nTPM
esophagus: 39 nTPM
salivary gland: 37 nTPM

Single-cell type

esophageal apical cells: 1,130 nCPM
suprabasal keratinocytes: 27 nCPM
esophageal suprabasal cells: 5.8 nCPM
esophageal basal cells: 3 nCPM
myosatellite cells: 1.2 nCPM
fibroblasts: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0.02
gnomAD missense Z: -0.77
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

keratinization

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Keratinization

InteractionsUniProt · HPA

Protein binding partners of LCE3D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CYSRT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCE3D as an antibody target. Whether an autoantibody or antibody against LCE3D could matter depends on whether native LCE3D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCE3D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LCE3D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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