LCE1C
Late cornified envelope protein 1C
Also known as: LCE1C_HUMAN, LEP3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T751
- Gene
- LCE1C
- Ensembl
- ENSG00000197084
- Chromosome
- 1
- Canonical length
- 118 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
118 residues, UniProt reviewed canonical sequence.
>Q5T751|LCE1C
1 MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGSC
61 GSSSGGCCSS GGGGCCLSHH RRRRSHCHRP QSSGCCSQPS GGSSCCGGGS GQHSGGCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LCE1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.74
- Highest tissue expression
- 535 nTPM
Expression across tissuesHPA
Tissue
- skin: 535 nTPM
- breast: 26 nTPM
- cervix: 5 nTPM
- skeletal muscle: 3.8 nTPM
- salivary gland: 0.9 nTPM
- esophagus: 0.6 nTPM
Single-cell type
- basal keratinocytes: 11 nCPM
- esophageal basal cells: 6.4 nCPM
- suprabasal keratinocytes: 2 nCPM
- epididymal efferent duct ciliated cells: 1.3 nCPM
- esophageal suprabasal cells: 1.1 nCPM
- bergmann glia: 0.9 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.1 nTPM
- medulla oblongata: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.86
- gnomAD pLI
- 0.03
- gnomAD missense Z
- -0.57
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LCE1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LCE1C as an antibody target. Whether an autoantibody or antibody against LCE1C could matter depends on whether native LCE1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LCE1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LCE1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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