LCE3C
Late cornified envelope protein 3C
Also known as: LCE3C_HUMAN, LEP15, SPRL3A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T5A8
- Gene
- LCE3C
- Ensembl
- ENSG00000244057
- Chromosome
- 1
- Canonical length
- 94 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and killing of cells of another organism. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
94 residues, UniProt reviewed canonical sequence.
>Q5T5A8|LCE3C
1 MSCQQNQQQC QPPPSCPSPK CPPKSPAQCL PPPSSDCALS SGGCGPSSES GCCLSHHRHF
61 RSHQCRRQRS NSCDRGSGQQ GGGSCRGHGS GGCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LCE3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.73
- Highest tissue expression
- 23 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 23 nTPM
- skin: 1.6 nTPM
- testis: 0.2 nTPM
- esophagus: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
Single-cell type
- esophageal apical cells: 2 nCPM
- late spermatids: 1 nCPM
- early spermatids: 0.5 nCPM
- undifferentiated spermatogonia: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.47
- gnomAD pLI
- 0.48
- gnomAD missense Z
- 0.94
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LCE3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LCE3C as an antibody target. Whether an autoantibody or antibody against LCE3C could matter depends on whether native LCE3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LCE3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LCE3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...