Seroatlas · Human Serome Atlas

LCE1E

Late cornified envelope protein 1E

Also known as: LCE1E_HUMAN, LEP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T753
Gene
LCE1E
Ensembl
ENSG00000186226
Chromosome
1
Canonical length
118 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>Q5T753|LCE1E
     1  MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGSC
    61  GSSSGGCCSS GGGGCCLSHH RHHRSHRHRP QSSDCCSQPS GGSSCCGGGS GQHSGGCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCE1E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.74
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • skin: 58 nTPM
  • urinary bladder: 1 nTPM
  • skeletal muscle: 0.5 nTPM
  • breast: 0.3 nTPM
  • rectum: 0.2 nTPM
  • vagina: 0.2 nTPM

Single-cell type

  • urothelial cells: 1.7 nCPM
  • epididymal efferent duct ciliated cells: 0.8 nCPM
  • prostatic hillock cells: 0.7 nCPM
  • bergmann glia: 0.4 nCPM
  • suprabasal keratinocytes: 0.3 nCPM
  • basal keratinocytes: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebral cortex: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.66
gnomAD pLI
0.17
gnomAD missense Z
-1.14

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LCE1E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCE1E as an antibody target. Whether an autoantibody or antibody against LCE1E could matter depends on whether native LCE1E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCE1E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LCE1E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LCE1E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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